Editing Estrogen (section)

===Cosmetics===
Some hair [[shampoo]]s on the market include estrogens and placental extracts; others contain [[phytoestrogen]]s. In 1998, there were case reports of four prepubescent African-American girls developing breasts after exposure to these shampoos.<ref>{{Cite news | vauthors = Sanghavi DM | title=Preschool Puberty, and a Search for the Causes | newspaper = [[The New York Times]] | date = 17 October 2006 | url = https://www.nytimes.com/2006/10/17/science/17puberty.html |access-date=4 June 2008 }}</ref> In 1993, the FDA determined that not all [[over-the-counter drug|over-the-counter]] topically applied hormone-containing drug products for human use are [[generally recognized as safe and effective]] and are misbranded. An accompanying proposed rule deals with cosmetics, concluding that any use of natural estrogens in a cosmetic product makes the product an unapproved new drug and that any cosmetic using the term "hormone" in the text of its labeling or in its ingredient statement makes an implied drug claim, subjecting such a product to regulatory action.<ref name="FDA cosmetics">{{cite web |author=FDA | date=February 1995 |title=Products containing estrogenic hormones, placental extract or vitamins |work=Guide to Inspections of Cosmetic Product Manufacturers |url=https://www.fda.gov/ora/inspect_ref/igs/cosmet.html |access-date=24 October 2006 |archive-url = https://web.archive.org/web/20071014014542/https://www.fda.gov/ora/inspect_ref/igs/cosmet.html |archive-date = 14 October 2007}}</ref>

In addition to being considered misbranded drugs, products claiming to contain placental extract may also be deemed to be misbranded cosmetics if the extract has been prepared from placentas from which the hormones and other biologically active substances have been removed and the extracted substance consists principally of protein. The FDA recommends that this substance be identified by a name other than "placental extract" and describing its composition more accurately because consumers associate the name "placental extract" with a therapeutic use of some biological activity.<ref name="FDA cosmetics"/>