Editing Antidepressant (section)

===Selective serotonin reuptake inhibitors===
[[File:Paroxetine-2D-skeletal.svg|alt=refer to caption|thumb|2D chemical structure of Paxil ([[Paroxetine]]), a [[selective serotonin reuptake inhibitor]]]]
[[Selective serotonin reuptake inhibitor]]s (SSRIs) are believed to increase the [[extracellular]] level of the [[neurotransmitter]] serotonin by [[Reuptake inhibitor|limiting]] its [[reuptake|reabsorption]] into the [[presynaptic cell]], increasing the level of [[serotonin]] in the [[synaptic cleft]] available to bind to the [[postsynaptic receptor]]. They have varying degrees of selectivity for the other [[monoamine transporter]]s, with pure SSRIs having only weak affinity for the [[norepinephrine transporter|norepinephrine]] and [[dopamine transporter]]s.

SSRIs are the most widely prescribed antidepressants in many countries.<ref name="PRESCORN2004">{{cite book|vauthors=Preskorn SH, Ross R, Stanga CY|chapter=Selective Serotonin Reuptake Inhibitors|chapter-url=https://books.google.com/books?id=sO_hArhCxwMC&pg=PA241|veditors=Preskorn SH, Feighner HP, Stanga CY, Ross R|title=Antidepressants: Past, Present and Future|publisher=Springer|location=Berlin|year=2004|pages=241–62|isbn=978-3-540-43054-4}}</ref> The efficacy of SSRIs in mild or moderate cases of depression has been disputed.<ref name="JAMA2010">{{cite journal|vauthors=Fournier JC, DeRubeis RJ, Hollon SD, Dimidjian S, Amsterdam JD, Shelton RC, Fawcett J|title=Antidepressant drug effects and depression severity: a patient-level meta-analysis|journal=JAMA|volume=303|issue=1|pages=47–53|date=January 2010|pmid=20051569|pmc=3712503|doi=10.1001/jama.2009.1943}}</ref><ref name="Kramer">{{cite news|vauthors=Kramer P|title=In Defense of Antidepressants|url=https://www.nytimes.com/2011/07/10/opinion/sunday/10antidepressants.html|access-date=13 July 2011|newspaper=The New York Times|date=7 September 2011|url-status=live|archive-url=https://web.archive.org/web/20110712053223/http://www.nytimes.com/2011/07/10/opinion/sunday/10antidepressants.html|archive-date=12 July 2011}}</ref><ref name="Pies">{{cite journal|vauthors=Pies R|title=Antidepressants work, sort of—our system of care does not|journal=Journal of Clinical Psychopharmacology|volume=30|issue=2|pages=101–104|date=April 2010|pmid=20520282|doi=10.1097/JCP.0b013e3181d52dea|url=https://zenodo.org/record/890741}}</ref><ref>{{cite journal|vauthors=Pies RW|title=Antidepressants: Conundrums and Complexities of Efficacy Studies|journal=Journal of Clinical Psychopharmacology|volume=36|issue=1|pages=1–4|date=February 2016|pmid=26658086|doi=10.1097/jcp.0000000000000455|s2cid=28469650|url=https://zenodo.org/record/890747}}</ref>