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===Alternative medicine=== Researchers are investigating complementary therapies as treatment for people with acne.<ref name="CaoYang2015">{{cite journal | vauthors = Cao H, Yang G, Wang Y, Liu JP, Smith CA, Luo H, Liu Y | title = Complementary therapies for acne vulgaris | journal = The Cochrane Database of Systematic Reviews | volume = 1 | pages = CD009436 | date = January 2015 | issue = 1 | pmid = 25597924 | pmc = 4486007 | doi = 10.1002/14651858.CD009436.pub2 | type = Systematic Review & Meta-Analysis }}</ref> [[Evidence-based medicine#Assessing the quality of evidence|Low-quality evidence]] suggests topical application of [[tea tree oil]] or [[bee venom]] may reduce the total number of skin lesions in those with acne.<ref name="CaoYang2015"/> Tea tree oil appears to be approximately as effective as [[benzoyl peroxide]] or salicylic acid but is associated with [[allergic contact dermatitis]].<ref name=Vary2015/> Proposed mechanisms for tea tree oil's anti-acne effects include antibacterial action against ''C. acnes'' and anti-inflammatory properties.<ref name=Hammer2015/> Numerous other plant-derived therapies have demonstrated positive effects against acne (e.g., [[basil oil]]; [[oligosaccharide]]s from [[seaweed]]; however, few well-done studies have examined their use for this purpose.<ref name="Fisk2014">{{cite journal | vauthors = Fisk WA, Lev-Tov HA, Sivamani RK | title = Botanical and phytochemical therapy of acne: a systematic review | journal = Phytotherapy Research | volume = 28 | issue = 8 | pages = 1137β52 | date = August 2014 | pmid = 25098271 | doi = 10.1002/ptr.5125 | s2cid = 10111211 | type = Systematic Review }}</ref> There is a lack of high-quality evidence for the use of [[acupuncture]], [[Herbalism|herbal medicine]], or [[cupping therapy]] for acne.<ref name=CaoYang2015/>
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