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===Parenteral phase=== The severity of symptoms caused by larval migration from the intestines depends on the number of larvae produced. As the larvae migrate through tissue and vessels, the body's inflammatory response results in [[edema]], muscle pain, fever, and weakness. A classic sign of trichinosis is [[periorbital edema]], swelling around the eyes, which may be caused by [[vasculitis]]. [[Splinter hemorrhage]] in the nails is also a common symptom.<ref name=eight>John D. and William A. Petri. Markell and Voge's Medical Parasitology. 9th ed. Philadelphia: Saunders, 2006.</ref> They may very rarely cause enough damage to produce serious neurological deficits (such as [[ataxia]] or [[respiratory paralysis]]) from worms entering the [[central nervous system]] (CNS), which is compromised by trichinosis in 10β24% of reported cases of [[cerebral venous sinus thrombosis]], a very rare form of stroke (three or four cases per million annual incidence in adults).<ref name=sixteen>{{cite journal |last1=Evans |first1=R. W. |last2=Patter |first2=B. M. | year = 1982 | title = Trichinosis associated with superior sagittal sinus thrombosis | journal = Annals of Neurology | volume = 11 | issue = 2| pages = 216β17 | doi=10.1002/ana.410110225 | pmid=7073258|s2cid=32598996 }}</ref> Trichinosis can be fatal depending on the severity of the infection; death can occur 4β6 weeks after the infection,<ref name="two"/> and is usually caused by [[myocarditis]], [[encephalitis]], or [[pneumonia]].<ref name="three">{{cite journal | author = Pozio E | date = Dec 2002 | title = Trichinella zimbabwensis n.sp. (Nematoda), a new non-encapsulated species from crocodiles (Crocodylus niloticus) in Zimbabwe also infecting mammals | journal = Int J Parasitol | volume = 32 | issue = 14| pages = 1787β99 | pmid = 12464425 | doi=10.1016/s0020-7519(02)00139-x|display-authors=etal}}</ref>
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