Editing Tetrahydrocannabinol (section)

==Overdose==
The [[median lethal dose]] of THC in humans is not fully known as there is conflicting evidence. A 1972 study gave up to 90&nbsp;mg/kg of THC to dogs and monkeys without any lethal effects. Some rats died within 72 hours after a dose of up to 36&nbsp;mg/kg.<ref>{{cite journal |vauthors=Thompson GR, Rosenkrantz H, Schaeppi UH, Braude MC |title=Comparison of acute oral toxicity of cannabinoids in rats, dogs and monkeys |journal=Toxicology and Applied Pharmacology |volume=25 |issue=3 |pages=363–72 |date=July 1973 |pmid=4199474 |doi=10.1016/0041-008X(73)90310-4 |bibcode=1973ToxAP..25..363T |quote=In dogs and monkeys, single oral doses of Δ9-THC and Δ8-THC between 3000 and 9000/mg/kg were nonlethal.}}</ref> A 2014 case study based on the toxicology reports and relative testimony in two separate cases gave the median lethal dose in humans at 30&nbsp;mg/kg (2.1 grams THC for a person who weighs 70&nbsp;kg; 154 lb; 11 stone), observing [[cardiovascular]] death in the one otherwise healthy subject of the two cases studied.<ref>{{cite journal |vauthors=Hartung B, Kauferstein S, Ritz-Timme S, Daldrup T |title=Sudden unexpected death under acute influence of cannabis |journal=Forensic Science International |volume=237 |pages=e11–e13 |date=April 2014 |pmid=24598271 |doi=10.1016/j.forsciint.2014.02.001 }}</ref> A different 1972 study gave the median lethal dose for intravenous THC in mice and rats at 30–40&nbsp;mg/kg.<ref>{{cite journal |vauthors=Nahas GC |title=UNODC - Bulletin on Narcotics - 1972 Issue 2 - 002 |journal=United Nations: Office on Drugs and Crime |date=1 January 1972 |pages=11–27 |url=https://www.unodc.org/unodc/en/data-and-analysis/bulletin/bulletin_1972-01-01_2_page003.html |language=en |access-date=2022-12-11 |archive-date=2022-12-11 |archive-url=https://web.archive.org/web/20221211181839/https://www.unodc.org/unodc/en/data-and-analysis/bulletin/bulletin_1972-01-01_2_page003.html |url-status=live }}</ref> A 2020 fact sheet published by the U.S. [[Drug Enforcement Administration]] stated that "[n]o deaths from overdose of marijuana have been reported."<ref>{{cite web |url=https://www.dea.gov/sites/default/files/2020-06/Marijuana-Cannabis-2020_0.pdf |title=Drug Fact Sheet: Marijuana/Cannabis |work=[[Drug Enforcement Administration]] |publisher=[[United States Department of Justice]] |date=April 2020 |access-date=9 February 2025 }}</ref>