Editing Sertraline (section)

====Comparison with other antidepressants====
In general, sertraline efficacy is similar to that of other antidepressants.<ref name="pmid11420570">{{cite journal | vauthors = MacQueen G, Born L, Steiner M | title = The selective serotonin reuptake inhibitor sertraline: its profile and use in psychiatric disorders | journal = CNS Drug Reviews | volume = 7 | issue = 1 | pages = 1–24 | date = 2001 | pmid = 11420570 | pmc = 6741657 | doi = 10.1111/j.1527-3458.2001.tb00188.x }}</ref> For example, a meta-analysis of 12 new-generation antidepressants showed that sertraline and [[escitalopram]] are the best in terms of efficacy and acceptability in the acute-phase treatment of adults with depression.<ref name=cipriani>{{cite journal | vauthors = Cipriani A, Furukawa TA, Salanti G, Geddes JR, Higgins JP, Churchill R, Watanabe N, Nakagawa A, Omori IM, McGuire H, Tansella M, Barbui C | s2cid = 35858125 | title = Comparative efficacy and acceptability of 12 new-generation antidepressants: a multiple-treatments meta-analysis | journal = Lancet | volume = 373 | issue = 9665 | pages = 746–58 | date = February 2009 | pmid = 19185342 | doi = 10.1016/S0140-6736(09)60046-5 }}; {{lay source |template=cite news | vauthors = Kahn M |url=https://www.reuters.com/article/health-depression-idUKLS30284720090129 |title= Zoloft, Lexapro best new antidepressants-study |date=28 January 2009 |agency= |work= Reuters |location=}}</ref> Comparative clinical trials demonstrated that sertraline is similar in efficacy against depression to [[moclobemide]],<ref name="pmid17168253">{{cite journal | vauthors = Papakostas GI, Fava M | title = A metaanalysis of clinical trials comparing moclobemide with selective serotonin reuptake inhibitors for the treatment of major depressive disorder | journal = Canadian Journal of Psychiatry | volume = 51 | issue = 12 | pages = 783–90 | date = October 2006 | pmid = 17168253 | doi = 10.1177/070674370605101208 | doi-access = free }}</ref> [[nefazodone]],<ref name="pmid8626364">{{cite journal | vauthors = Feiger A, Kiev A, Shrivastava RK, Wisselink PG, Wilcox CS | title = Nefazodone versus sertraline in outpatients with major depression: focus on efficacy, tolerability, and effects on sexual function and satisfaction | journal = The Journal of Clinical Psychiatry | volume = 57 | issue = Suppl 2 | pages = 53–62 | year = 1996 | pmid = 8626364 | series = 57 }}</ref> [[escitalopram]], [[bupropion]],<ref name="pmid9448656">{{cite journal | vauthors = Kavoussi RJ, Segraves RT, Hughes AR, Ascher JA, Johnston JA | title = Double-blind comparison of bupropion sustained release and sertraline in depressed outpatients | journal = The Journal of Clinical Psychiatry | volume = 58 | issue = 12 | pages = 532–7 | date = December 1997 | pmid = 9448656 | doi = 10.4088/JCP.v58n1204 }}</ref> [[citalopram]], [[fluvoxamine]], [[paroxetine]],<ref name=cipriani /> [[venlafaxine]],<ref name="pmid16870212"/> and [[mirtazapine]].<ref name="pmid16172440">For the review, see:{{cite journal | vauthors = Hansen RA, Gartlehner G, Lohr KN, Gaynes BN, Carey TS | s2cid = 10321621 | title = Efficacy and safety of second-generation antidepressants in the treatment of major depressive disorder | journal = Annals of Internal Medicine | volume = 143 | issue = 6 | pages = 415–26 | date = September 2005 | pmid = 16172440 | doi = 10.7326/0003-4819-143-6-200509200-00006 }}</ref> Sertraline may be more efficacious for the treatment of depression in the acute phase (first four weeks) than [[fluoxetine]].<ref>{{cite journal | vauthors = Cipriani A, La Ferla T, Furukawa TA, Signoretti A, Nakagawa A, Churchill R, McGuire H, Barbui C | title = Sertraline versus other antidepressive agents for depression | journal = The Cochrane Database of Systematic Reviews | issue = 4 | pages = CD006117 | date = April 2010 | pmid = 20393946 | pmc = 4163971 | doi = 10.1002/14651858.CD006117.pub4 }}</ref>

There are differences between sertraline and some other antidepressants in their efficacy in the treatment of different subtypes of depression and in their adverse effects. For severe depression, sertraline is as good as [[clomipramine]] but is better tolerated.<ref name="pmid16870212">{{cite journal |vauthors=Nemeroff CB |title=The burden of severe depression: a review of diagnostic challenges and treatment alternatives |journal=J Psychiatr Res |volume=41 |issue=3–4 |pages=189–206 |date=2007 |pmid=16870212 |doi=10.1016/j.jpsychires.2006.05.008 }}</ref> Sertraline appears to work better in [[melancholic depression]] than fluoxetine, [[paroxetine]], and [[mianserin]] and is similar to the [[tricyclic antidepressants]] such as [[amitriptyline]] and [[clomipramine]].<ref name="pmid11420570"/> In the treatment of depression accompanied by [[OCD]], sertraline performs significantly better than [[desipramine]] on the measures of both OCD and depression.<ref name="pmid21456103"/><ref name="pmid25969470">{{cite journal |vauthors=Cleare A, Pariante CM, Young AH, Anderson IM, Christmas D, Cowen PJ, Dickens C, Ferrier IN, Geddes J, Gilbody S, Haddad PM, Katona C, Lewis G, Malizia A, McAllister-Williams RH, Ramchandani P, Scott J, Taylor D, Uher R |title=Evidence-based guidelines for treating depressive disorders with antidepressants: A revision of the 2008 British Association for Psychopharmacology guidelines |journal=J Psychopharmacol |volume=29 |issue=5 |pages=459–525 |date=May 2015 |pmid=25969470 |doi=10.1177/0269881115581093 |s2cid=8142581 |url=https://kclpure.kcl.ac.uk/ws/files/52545391/PMH_24_3_15_British_Association_forPsychopharmacology_Final_Reconciliation_Draft_2_.docx }}</ref> Sertraline is equivalent to imipramine for the treatment of depression with co-morbid panic disorder, but it is better tolerated.<ref name="pmid12516310">{{cite journal |vauthors=Bandelow B, Zohar J, Hollander E, Kasper S, Möller HJ |title=World Federation of Societies of Biological Psychiatry (WFSBP) guidelines for the pharmacological treatment of anxiety, obsessive-compulsive and posttraumatic stress disorders |journal=World J Biol Psychiatry |volume=3 |issue=4 |pages=171–99 |date=October 2002 |pmid=12516310 |doi=10.3109/15622970209150621 |doi-access=free }}</ref> Compared with amitriptyline, sertraline offered a greater overall improvement in [[quality of life]] of depressed patients.<ref name="pmid11420570" />