Editing Roundup (herbicide) (section)

===Human===
The acute oral toxicity for mammals is low,<ref name=vbruggen/> but death has been reported after deliberate overdose of [[Dose–response relationship|concentrated]] Roundup.<ref name="pmid22835958">{{cite journal |vauthors= Sribanditmongkol P, Jutavijittum P, Pongraveevongsa P, Wunnapuk K, Durongkadech P |title= Pathological and toxicological findings in glyphosate-surfactant herbicide fatality: a case report |journal= The American Journal of Forensic Medicine and Pathology |volume= 33 |issue=3 |pages= 234–7 |date= Sep 2012 |doi= 10.1097/PAF.0b013e31824b936c |pmid= 22835958 |s2cid= 3457850 }}</ref> The surfactants in glyphosate formulations can increase the relative acute toxicity of the formulation.<ref name="Bradberry_2004">{{cite journal |vauthors= Bradberry SM, Proudfoot AT, Vale JA |title= Glyphosate poisoning |journal = Toxicological Reviews |volume= 23 |issue=3 |pages= 159–67 |year= 2004 |pmid= 15862083 |doi= 10.2165/00139709-200423030-00003 |s2cid= 5636017 }}</ref> Surfactants generally do not, however, cause [[Drug interaction#Synergy and antagonism|synergistic effects]] (as opposed to additive effects) that increase the acute toxicity of glyphosate within a formulation.<ref name="Bradberry_2004"/> The surfactant POEA is not considered an acute toxicity hazard, and has an oral toxicity similar to [[vitamin A]] and less toxic than [[aspirin]].<ref>{{cite journal |last1= Williams |first1=Gary M. |last2=Kroes |first2= Robert |last3=Munro |first3=Ian C. |title= Safety Evaluation and Risk Assessment of the Herbicide Roundup and Its Active Ingredient, Glyphosate, for Humans |journal=[[Regulatory Toxicology and Pharmacology]] |date=April 2000 |volume=31 |issue=2 |pages=117–165 |doi= 10.1006/rtph.1999.1371 |pmid=10854122 |s2cid=19831028 }}</ref> Deliberate ingestion of Roundup ranging from 85 to 200 ml (of 41% solution) has resulted in death within hours of ingestion, although it has also been ingested in quantities as large as 500 ml with only mild or moderate symptoms.<ref name="pmid1673618">{{cite journal |vauthors=Talbot AR, Shiaw MH, Huang JS, Yang SF, Goo TS, Wang SH, Chen CL, Sanford TR |title=Acute poisoning with a glyphosate-surfactant herbicide ('Roundup'): a review of 93 cases |journal=Human & Experimental Toxicology |volume=10 |issue=1 |pages=1–8 |date=Jan 1991 |pmid=1673618 |doi= 10.1177/096032719101000101|s2cid=8028945 }}</ref> Consumption of over 85 ml of concentrated product is likely to cause serious symptoms in adults, including burns due to corrosive effects as well as kidney and liver damage. More severe cases lead to "respiratory distress, impaired consciousness, [[pulmonary edema]], infiltration on chest X-ray, shock, arrhythmias, [[kidney failure]] requiring haemodialysis, metabolic acidosis, and hyperkalaemia" and death is often preceded by [[bradycardia]] and [[ventricular arrhythmia]]s.<ref name="Bradberry_2004"/>

Skin exposure can cause irritation, and [[Contact dermatitis#Photocontact dermatitis|photocontact dermatitis]] has been occasionally reported. Severe skin burns are very rare.<ref name="Bradberry_2004"/> In a 2017 risk assessment, the European Chemicals Agency (ECHA) wrote: "There is very limited information on skin irritation in humans. Where skin irritation has been reported, it is unclear whether it is related to glyphosate or co-formulants in glyphosate-containing herbicide formulations." The ECHA concluded that available human data was insufficient to support classification for skin corrosion or irritation.<ref>[https://echa.europa.eu/documents/10162/2f8b5c7f-030f-5d3a-e87e-0262fb392f38 Committee of Risk Assessment Opinion proposing harmonised classification and labelling at EU level of glyphosate (ISO); N-(phosphonomethyl)glycine]</ref>

Inhalation is a minor route of exposure, but spray mist may cause oral or nasal discomfort, an unpleasant taste in the mouth, or tingling and irritation in the throat. Eye exposure may lead to mild conjunctivitis. Superficial corneal injury is possible if irrigation is delayed or inadequate.<ref name="Bradberry_2004"/>