Editing Respiratory complex I (section)

=== Overall mechanism ===
All redox reactions take place in the hydrophilic domain of complex I. NADH initially binds to complex I, and transfers two electrons to the [[flavin mononucleotide]] (FMN) prosthetic group of the enzyme, creating FMNH<sub>2</sub>. The electron acceptor – the isoalloxazine ring – of FMN is identical to that of [[Flavin adenine dinucleotide|FAD]]. The electrons are then transferred through the FMN via a series of [[Iron–sulfur protein|iron-sulfur (Fe-S) clusters]],<ref name=":0" /> and finally to [[coenzyme Q10]] (ubiquinone). This electron flow changes the redox state of the protein, inducing conformational changes of the protein which alters the p''K'' values of ionizable side chain, and causes four hydrogen ions to be pumped out of the mitochondrial matrix.<ref name="BioChem">{{cite book | title = Principles of Biochemistry, 3rd Edition | chapter = Chapter 18, Mitochondrial ATP synthesis | vauthors = Voet DJ, Voet GJ, Pratt CW | publisher = Wiley | year = 2008 | isbn = 978-0-470-23396-2 | page = 608 }}</ref> [[Ubiquinone]] (CoQ) accepts two electrons to be reduced to [[ubiquinol]] (CoQH<sub>2</sub>).<ref name="Berg"/>