Editing Prostaglandin (section)

=== Biosynthesis ===
[[File:Eicosanoid synthesis.svg|thumb|300px|[[Biosynthesis]] of eicosanoids]]
Prostaglandins are found in most tissues and organs. They are [[biosynthesis|produced]] by almost all nucleated cells. They are [[autocrine]] and [[paracrine]] lipid mediators that act upon [[platelet]]s, [[endothelium]], [[uterus|uterine]] and [[mast cell]]s. They are synthesized in the cell from the [[fatty acid]] [[arachidonic acid]].<ref name=":0" />

[[Arachidonic acid]] is created from [[diacylglycerol]] via [[phospholipase A2|phospholipase-A<sub>2</sub>]], then brought to either the [[Cyclooxygenase|cyclooxygenase pathway]] or the [[Lipoxygenase|lipoxygenase pathway]]. The cyclooxygenase pathway produces [[thromboxane]], [[prostacyclin]] and prostaglandin D, E and F. Alternatively, the lipoxygenase enzyme pathway is active in [[leukocyte]]s and in [[macrophage]]s and synthesizes [[leukotrienes]].{{citation needed|date=January 2024}}