Editing Pope Innocent IX (section)

===Episcopate and cardinalate===
In 1560, Facchinetti was named as the [[Bishop of Nicastro]],{{sfn|Martin|1993|p=183}} in [[Calabria]], and in 1562 was present at the [[Council of Trent]]. He was the first bishop to actually reside in the diocese in three decades. [[Pope Pius V]] (1566–1572) sent him as [[papal nuncio]] to [[Republic of Venice|Venice]] in 1566{{sfn|Martin|1993|p=183}} to further the papal alliance with [[Habsburg Spain|Spain]] and Venice against the [[Ottoman Empire|Turks]], which ultimately resulted in the victory of [[Battle of Lepanto|Lepanto]] in 1571. He was recalled from Venice in 1572 and was made the Prior Commendatario of [[Sant'Andrea, Padua|Sant'Andrea]] di Carmignano in the [[Roman Catholic Diocese of Padua|diocese of Padua]] from 1576 to 1587.{{sfn|McBrien|2000|p=295}}

Relinquishing his [[episcopal see|see]] to pursue his career in Rome in 1575 and also because of health reasons, he was named the Titular [[Latin Patriarch of Jerusalem]] in 1572.{{sfn|Weber|1910}} He occupied that post until he was made a cardinal. [[Pope Gregory XIII]] made him a [[Cardinal (Catholic Church)|cardinal]] on 12 December 1583 as the Cardinal-Priest of [[Santi Quattro Coronati]] and he was to receive the red hat and title on 9 January 1584. [[Pope Gregory XIV]] made him the Prefect of the Apostolic Signatura in 1591.