Editing Plague (disease) (section)

===Septicemic plague===
{{Main|Septicemic plague}}
[[File:PlagueTypes.jpg|thumb|Septicemic plague resulting in necrosis]]
Lymphatics ultimately drain into the bloodstream, so the plague bacteria may enter the blood and travel to almost any part of the body. In [[septicemia|septicemic]] plague, bacterial endotoxins cause [[disseminated intravascular coagulation]] (DIC), causing tiny clots throughout the body and possibly ischemic necrosis (tissue death due to lack of circulation/perfusion to that tissue) from the clots. DIC results in depletion of the body's clotting resources so that it can no longer control bleeding. Consequently, there is bleeding into the skin and other organs, which can cause red and/or black patchy rash and hemoptysis/hematemesis (coughing up/ vomiting of blood). There are bumps on the skin that look somewhat like insect bites; these are usually red, and sometimes white in the centre. Untreated, the septicemic plague is usually fatal. Early treatment with [[antibiotics]] reduces the mortality rate to between 4 and 15 per cent.<ref name="Wagle1948">{{cite journal| author=Wagle PM| title=Recent advances in the treatment of bubonic plague| journal=Indian J Med Sci| year=1948| volume=2| pages=489–94}}</ref><ref name="Meyer1950">{{cite journal| author=Meyer KF| title=Modern therapy of plague| year=1950| journal=J Am Med Assoc| volume=144| pages=982–85| pmid=14774219| issue=12| doi=10.1001/jama.1950.02920120006003}}</ref><ref name="DattGupta1948">{{cite journal| author=Datt Gupta AK| title=A short note on plague cases treated at Campbell Hospital| journal=Ind Med Gaz| year=1948| volume=83| issue=3| pages=150–51| pmid=29014753| pmc=5190352}}</ref>