Editing Phencyclidine (section)

===Addiction===
PCP is self-administered and induces [[ΔFosB]] expression in the [[D1-type]] [[medium spiny neuron]]s of the [[nucleus accumbens]],<ref name="NHM-PCP and ketamine">{{cite book |vauthors=Malenka RC, Nestler EJ, Hyman SE |veditors=Sydor A, Brown RY | title = Molecular Neuropharmacology: A Foundation for Clinical Neuroscience | year = 2009 | publisher = McGraw-Hill Medical | location = New York | isbn = 9780071481274 | pages = 374–375 | edition = 2nd | chapter = Chapter 15: Reinforcement and Addictive Disorders}}</ref><ref name="PCP ΔFosB">{{cite journal| vauthors = Nestler EJ |title=Review. Transcriptional mechanisms of addiction: role of DeltaFosB|journal=Philos. Trans. R. Soc. Lond. B Biol. Sci.|volume=363|issue=1507|pages=3245–3255|date=October 12, 2008|pmid=18640924|doi=10.1098/rstb.2008.0067|pmc=2607320}}{{cite journal|title=Table 1: Drugs of abuse known to induce ΔFosB in nucleus accumbens after chronic administration|pmc=2607320|pmid=18640924|doi=10.1098/rstb.2008.0067|volume=363|issue=1507|date=October 2008|journal=Philos. Trans. R. Soc. Lond. B Biol. Sci.|pages=3245–55|vauthors=Nestler EJ}}</ref> and accordingly, excessive PCP use is known to cause [[addiction]].<ref name="NHM-PCP and ketamine"/> PCP's [[rewarding]] and [[reinforcing]] effects are at least partly mediated by blocking the [[NMDA receptor]]s in the glutamatergic inputs to D1-type medium spiny neurons in the nucleus accumbens.<ref name="NHM-PCP and ketamine"/> PCP has been shown to produce [[conditioned place aversion]] and [[conditioned place preference]] in animal studies.<ref>{{cite journal | vauthors = Noda Y, Nabeshima T | title = Neuronal mechanisms of phencyclidine-induced place aversion and preference in the conditioned place preference task | journal = Methods and Findings in Experimental and Clinical Pharmacology | volume = 20 | issue = 7 | pages = 607–11 | date = September 1998 | pmid = 9819806 | doi = 10.1358/mf.1998.20.7.485726 }}</ref>