Editing Periodontal disease (section)

==== Diabetes and periodontal disease ====
A positive correlation between raised levels of glucose within the blood and the onset or progression of periodontal disease has been shown in the current literature.

Data has also shown that there is a significant increase in the incidence or progression of periodontitis in patients with uncontrolled diabetes compared to those who do not have diabetes or have well-controlled diabetes. In uncontrolled diabetes, the formation of [[reactive oxygen species]] can damage cells such as those in the connective tissue of the periodontal ligament, resulting in cell [[necrosis]] or [[apoptosis]]. Furthermore, individuals with uncontrolled diabetes mellitus who have frequent exposure to periodontal pathogens have a greater immune response to these bacteria. This can subsequently cause and/or accelerate periodontal tissue destruction leading to periodontal disease.<ref>{{Cite journal |last1=Nascimento |first1=Gustavo G. |last2=Leite |first2=Fábio R. M. |last3=Vestergaard |first3=Peter |last4=Scheutz |first4=Flemming |last5=López |first5=Rodrigo |date=July 2018 |title=Does diabetes increase the risk of periodontitis? A systematic review and meta-regression analysis of longitudinal prospective studies |journal=Acta Diabetologica |volume=55 |issue=7 |pages=653–667 |doi=10.1007/s00592-018-1120-4 |issn=1432-5233 |pmid=29502214|s2cid=3689420 }}</ref>