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==Use during the twentieth century== During the twentieth century its use declined as governments regulated its ingredients (opium is a controlled substance in many countries). Beginning in late 2011, there was a period in which paregoric was not being manufactured in the United States. {{As of|2012|08}}, however, the manufacture of paregoric had resumed.<ref>{{cite web|title=Current Drug Shortages - Paregoric|url=http://www.ashp.org/DrugShortages/Current/bulletin.aspx?id=682|url-status=dead|archive-url=https://web.archive.org/web/20120320081547/http://www.ashp.org/DrugShortages/Current/Bulletin.aspx?id=682|archive-date=2012-03-20}}</ref> ===Regulation=== The early twentieth century brought increased regulation of all manner of narcotics, including paregoric, as the addictive properties of opium became more widely understood, and "patent medicines came under fire largely because of their mysterious compositions".<ref name="Inthe">''In the Arms of Morpheus: The Tragic History of Laudanum, Morphine, and Patent Medicines''," by Barbara Hodgson. Buffalo, New York: Firefly Books, 2001, page 126.</ref> In the United States, the [[Pure Food and Drug Act of 1906]] required that certain specified drugs, including [[alcohol (drug)|alcohol]], [[cocaine]], [[heroin]], [[morphine]], and cannabis, be accurately labeled with contents and dosage. Previously many drugs had been sold as patent medicines with secret ingredients or misleading labels. Cocaine, heroin, cannabis, and other such drugs continued to be legally available without prescription as long as they were labeled. It is estimated that sale of patent medicines containing opiates decreased by 33% after labeling was mandated.<ref>{{cite book|first=David F.|last= Musto|author-link=David F. Musto |year=1999|edition=3|title=The American Disease: Origins of Narcotic Control|publisher= Oxford University Press|isbn=0-19-512509-6|url= https://books.google.com/books?id=7VrQy2d8PxYC}}</ref> In 1906 in Britain and in 1908 in Canada "laws requiring disclosure of ingredients and limitation of narcotic content were instituted".<ref name="Inthe" /> The [[Harrison Narcotics Act]] of 1914 restricted the manufacture and distribution of opiates, including [[laudanum]], and coca derivatives in the United States; this was followed by France's ''Loi des stupefiants'' in 1916, and Britain's Dangerous Drugs Act in 1920.<ref name="Inthe" /> In the United States, the Harrison Narcotics Act of 1914<ref>The Harrison Narcotics Act (Public Law 63-223, December 17, 1914) was named for its sponsor, Sen. [[Francis Burton Harrison]] (1873β1957)</ref> regulated "opium or coca leaves, or any compound, manufacture, salt, derivative or preparation thereof", but not some medical products containing relatively low concentrations of these substances.<ref>According to one source, the 1914 Act "profoundly changed the nature of the narcotics problem in the United States. This law was intended as a revenue and control measure and was not designed to penalize the user of the drug, to whom no direct reference was made. The enforcement of the law was entrusted to the Bureau of Internal Revenue of the U.S. Treasury Department. It was evidently assumed or hoped that by requiring all persons who handled drugs to register with the government and maintain records the flow of drugs would be subject to public control. The act applied equally to cocaine and to opiates and made no distinctions between them. It required all persons who imported, manufactured, produced, compounded, sold, dealt in, dispensed, or gave away any derivative of opium or of coca leaves (cocaine) to register with the Collector of Internal Revenue, to pay special taxes, and to keep records of their transactions. Preparations containing minute quantities of cocaine or of opiates were exempted from the regulations." (See [http://www.drugtext.org/library/books/adopiates/chapter10.htm drugtext.org, visited February 6, 2008] {{webarchive|url=https://web.archive.org/web/20101022052621/http://www.drugtext.org/library/books/adopiates/chapter10.htm |date=October 22, 2010 }}).</ref> Paregoric was classified as an "Exempt Narcotic", as were other medical products containing small amounts of opium or their derivatives.<ref>Section 6 of the 1914 Act did not apply "to the sale, distribution, giving away, dispensing or possession of preparations and remedies which do not contain more than two grains of opium, or more than one-fourth of a grain of morphine, or more than one-eighth of grain of heroin, or more than one grain of codeine, or any salt or derivative of them, in one fluid ounce, or, if a solid or semisolid preparation, in one avoirdupois ounce; or to liniments, ointments, or other preparations which are prepared for external use only, except liniments, ointments, or other preparations which contain cocaine or any of its salts."</ref>
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