Editing Nicotinamide (section)

=== Acne ===
Nicotinamide [[Cream (pharmaceutical)|cream]] is used as a treatment for [[acne]].<ref name="BNF69" /> It has anti-inflammatory actions, which may benefit people with inflammatory skin conditions.<ref>{{cite journal | vauthors = Niren NM | title = Pharmacologic doses of nicotinamide in the treatment of inflammatory skin conditions: a review | journal = Cutis | volume = 77 | issue = 1 Suppl | pages = 11–6 | date = January 2006 | pmid = 16871774 }}</ref>

Nicotinamide increases the biosynthesis of [[ceramide]]s in human [[keratinocyte]]s in vitro and improves the epidermal permeability barrier in vivo.<ref>{{cite journal | vauthors = Tanno O, Ota Y, Kitamura N, Katsube T, Inoue S | title = Nicotinamide increases biosynthesis of ceramides as well as other stratum corneum lipids to improve the epidermal permeability barrier | journal = The British Journal of Dermatology | volume = 143 | issue = 3 | pages = 524–31 | date = September 2000 | pmid = 10971324 | doi = 10.1111/j.1365-2133.2000.03705.x | s2cid = 21874670 }}</ref> The application of 2% topical nicotinamide for 2 and 4 weeks has been found to be effective in lowering the [[Sebaceous gland|sebum]] excretion rate.<ref>{{cite journal | vauthors = Draelos ZD, Matsubara A, Smiles K | s2cid = 36713665 | title = The effect of 2% niacinamide on facial sebum production | journal = Journal of Cosmetic and Laser Therapy | volume = 8 | issue = 2 | pages = 96–101 | date = June 2006 | pmid = 16766489 | doi = 10.1080/14764170600717704 }}</ref> Nicotinamide has been shown to prevent ''[[Cutibacterium acnes]]''-induced activation of [[TLR2|toll-like receptor 2]], which ultimately results in the down-regulation of pro-inflammatory [[Interleukin 8|interleukin-8]] production.<ref>{{cite journal | vauthors = Kim J, Ochoa MT, Krutzik SR, Takeuchi O, Uematsu S, Legaspi AJ, Brightbill HD, Holland D, Cunliffe WJ, Akira S, Sieling PA, Godowski PJ, Modlin RL | title = Activation of toll-like receptor 2 in acne triggers inflammatory cytokine responses | journal = Journal of Immunology | volume = 169 | issue = 3 | pages = 1535–41 | date = August 2002 | pmid = 12133981 | pmc = 4636337 | doi = 10.4049/jimmunol.169.3.1535 }}</ref>