Editing Methadone (section)

=== Pain ===
Methadone is used as an [[analgesic]] in chronic pain, often in [[opioid rotation|rotation with other opioids]].<ref name="Kraychete_2012">{{cite journal | vauthors = Kraychete DC, Sakata RK | title = Use and rotation of opioids in chronic non-oncologic pain | journal = Revista Brasileira de Anestesiologia | volume = 62 | issue = 4 | pages = 554–562 | date = July 2012 | pmid = 22793972 | doi = 10.1016/S0034-7094(12)70155-1 | doi-access = free | title-link = doi }}</ref><ref name="Mercadante_2016">{{cite journal | vauthors = Mercadante S, Bruera E | title = Opioid switching in cancer pain: From the beginning to nowadays | journal = Critical Reviews in Oncology/Hematology | volume = 99 | pages = 241–248 | date = March 2016 | pmid = 26806145 | doi = 10.1016/j.critrevonc.2015.12.011 }}</ref> Due to its activity at the [[NMDA receptor]], it may be more effective against [[neuropathic pain]]; for the same reason, tolerance to the analgesic effects may be less than that of other opioids.<ref>{{cite journal | vauthors = Leppert W | title = The role of methadone in cancer pain treatment--a review | journal = International Journal of Clinical Practice | volume = 63 | issue = 7 | pages = 1095–1109 | date = July 2009 | pmid = 19570126 | doi = 10.1111/j.1742-1241.2008.01990.x | s2cid = 205875314 }}</ref><ref>{{cite journal | vauthors = Nicholson AB, Watson GR, Derry S, Wiffen PJ | title = Methadone for cancer pain | journal = The Cochrane Database of Systematic Reviews | volume = 2 | issue = 3 | pages = CD003971 | date = February 2017 | pmid = 28177515 | pmc = 6464101 | doi = 10.1002/14651858.CD003971.pub4 }}</ref>