Editing Melange (Dune) (section)

===Physiological side effects===
Extensive use of the drug tints the [[sclera]], [[cornea]], and [[iris (anatomy)|iris]] of the user to a dark shade of blue, called "blue-in-blue" or "the Eyes of Ibad",<ref>{{cite book |last=Herbert |first=Frank |title=Dune |url=https://archive.org/details/dune0000herb |url-access=registration |chapter=Terminology of the Imperium: Ibad, Eyes of |year=1965|quote=Ibad, Eyes of: characteristic effect of a diet high in melange wherein the whites and pupils of the eyes turn a deep blue (indicative of deep melange addiction).}}</ref> which is something of a source of pride among the Fremen and a symbol of their tribal bond. In ''Dune'', Paul initially has green eyes, but after several years on Arrakis they begin to take on the deep, uniform blue of the Fremen. On other planets, the addicted often use tinted [[contact lens]]es to hide this discoloration.<ref name="Farad'n">{{cite book |last=Herbert |first=Frank |title=Children of Dune |url=https://archive.org/details/childrenofdune1976herb |url-access=registration |year=1976 |publisher=Berkley Publishing Corporation |isbn=9780425043837 |quote=[[Farad'n]] touched his own eyelids, feeling the hard surfaces of the permanent contact lenses which concealed the total blue of his spice addiction.}}</ref><ref>In ''Heretics of Dune'' (1984), the Bene Gesserit [[Schwangyu]] notes that "Blue-in-blue eyes uncorrected by any lens gave [[Lucilla (Dune)|Lucilla]] a piercing expression that went with her long oval face." Herbert later writes of [[Duncan Idaho]] that "His first glimpse of Schwangyu had confronted him with eyes concealed behind contact lenses that simulated non-addict pupils and slightly bloodshot whites."</ref> In ''Dune'', [[Padishah Emperor]] [[Shaddam IV]] notes of two Guildsmen:<ref name="Dune"/>
{{blockquote|The taller of the two, though, held a hand to his left eye. As the Emperor watched, someone jostled the Guildsman's arm, the hand moved, and the eye was revealed. The man had lost one of his masking contact lenses, and the eye stared out a total blue so dark as to be almost black.}}

Melange is also highly addictive,<ref name="Addiction">{{cite book |last=Herbert |first=Frank |title=Dune |url=https://archive.org/details/dune0000herb |url-access=registration |chapter=Terminology of the Imperium: Melange|year=1965 |quote=The spice... is mildly addictive when taken in small quantities, severely addictive when imbibed in quantities above two grams daily per seventy kilos of body weight.}}</ref> and withdrawal means certain death.<ref name="SR 2021"/> [[Paul Atreides]] notes in ''Dune'' that the spice is "[a] poison—so subtle, so insidious... so irreversible. It won't even kill you unless you stop taking it."<ref name="Dune"/> When aerosolized and used as an [[inhalant]] in extremely high dosages—the standard practice for Guild Navigators—the drug alters the physiology of its user. In the first chapter of ''Dune Messiah'', Guild Navigator Edric is described in his tank of spice gas as "an elongated figure, vaguely humanoid with finned feet and hugely fanned membranous hands—a fish in a strange sea."<ref name="Messiah"/>

In ''Children of Dune'', the term "spice trance" is used to describe the effects of an overdose of spice. Alia had previously subjected herself to such an overdose late in ''Dune Messiah'', hoping to enhance her prescient visions. She achieves some success, but in ''Children of Dune'', [[Leto II Atreides|Leto II]] and [[Ghanima Atreides|Ghanima]] blame the trance for Alia's descent into [[Abomination (Dune)|Abomination]]. Fearful of the same fate, they resist Alia's urgings to undergo the spice trance themselves. The trial is later forced upon Leto at Jacurutu when it is suspected that he too is an Abomination. Leto survives the challenge and escapes, but is left changed. Unlike Alia, however, he remains in control, and the spice trance opens his eyes to the [[Golden Path (Dune)|Golden Path]] that will ultimately save humanity.<ref name="Children"/>