Editing Lipid-lowering agent (section)

=== Alternative ===

* [[Lecithin]] has been shown to effectively decrease cholesterol concentration by 33%, lower LDL by 38% and increase HDL by 46%.<ref>{{Cite journal | doi=10.1002/ptr.2650090814|title = Clinical evaluation of lecithin as a lipid-lowering agent| journal=Phytotherapy Research| volume=9| issue=8| pages=597–599|year = 1995|last1 = Wójcicki|first1 = J.| last2=Pawlik| first2=A.| last3=Samochowiec| first3=L.| last4=Kaldo??Ska| first4=M.| last5=Myśliwiec| first5=Z.|s2cid = 71032494}}</ref>{{primary source inline|date=February 2024}}
* [[Phytosterol]]s may be found naturally in plants. Similar to ezetimibe, phytosterols reduce the absorption of cholesterol in the gut, so they are most effective when consumed with meals. However, their precise mechanism of action differs from ezetimibe.
* [[Omega-3 fatty acid|Omega-3]] supplements taken at high doses can reduce levels of triglycerides.<ref>{{Cite web|url=https://www.nccih.nih.gov/health/omega3-supplements-in-depth|title=Omega-3 Supplements: In Depth|date=2018-05-01|website=NCCIH|language=en|access-date=2021-02-02}}</ref> They are associated with a very modest increase in LDL (~5%).
* [[Choline]]
* [[Pycnogenol]]<ref>{{cite journal |last1=Stough |first1=Con K |last2=Pase |first2=Matthew P |last3=Cropley |first3=Vanessa |last4=Myers |first4=Stephen |last5=Nolidin |first5=Karen |last6=King |first6=Rebecca |last7=Camfield |first7=David |last8=Wesnes |first8=Keith |last9=Pipingas |first9=Andrew |last10=Croft |first10=Kevin |last11=Chang |first11=Dennis |last12=Scholey |first12=Andrew B |title=A randomized controlled trial investigating the effect of Pycnogenol and BacopaCDRI08 herbal medicines on cognitive, cardiovascular, and biochemical functioning in cognitively healthy elderly people: the Australian Research Council Longevity Intervention (ARCLI) study protocol (ANZCTR12611000487910) |journal=Nutrition Journal |date=December 2012 |volume=11 |issue=1 |pages=11 |doi=10.1186/1475-2891-11-11|pmid=22390677 | pmc=3310777 |doi-access=free }}</ref>
* [[Berberine]]<ref>{{cite journal |last1=Doggrell |first1=SA |title=Berberine--a novel approach to cholesterol lowering. |journal=Expert Opinion on Investigational Drugs |date=May 2005 |volume=14 |issue=5 |pages=683–5 |doi=10.1517/13543784.14.5.683 |pmid=15926873 |s2cid=1708378 |url=https://pubmed.ncbi.nlm.nih.gov/15926873/}}</ref><ref>{{cite journal |last1=Koppen |first1=Laura M. |last2=Whitaker |first2=Andrea |last3=Rosene |first3=Audrey |last4=Beckett |first4=Robert D. |title=Efficacy of Berberine Alone and in Combination for the Treatment of Hyperlipidemia: A Systematic Review |journal=Journal of Evidence-Based Complementary & Alternative Medicine |date=October 2017 |volume=22 |issue=4 |pages=956–968 |doi=10.1177/2156587216687695 |pmid=29228784 |pmc=5871262 |language=en}}</ref>
* [[Red yeast rice]]<ref>{{cite journal |last1=Cicero |first1=Arrigo F. G. |last2=Fogacci |first2=Federica |last3=Zambon |first3=Alberto |title=Red Yeast Rice for Hypercholesterolemia: JACC Focus Seminar |journal=Journal of the American College of Cardiology |date=9 February 2021 |volume=77 |issue=5 |pages=620–628 |doi=10.1016/j.jacc.2020.11.056 |pmid=33538260 |s2cid=231803755 |url=https://www.sciencedirect.com/science/article/pii/S0735109720379997 |language=en |issn=0735-1097|hdl=11585/827471 |hdl-access=free }}</ref> is the natural source from which statins were discovered, but the FDA currently disallows any RYR with significant amounts of statin to be sold as a dietary supplement <ref name=Pharmanex2001>{{cite web |url=https://casetext.com/case/pharmanex-inc-v-shalala-1 |title=Pharmanex Inc. v. Shalala, United States District Court, D. Utah, Central Division Mar 1, 2001 Case No. 2:97CV262K |website=Casetext |access-date=21 June 2019}}</ref>
* [[Boswellia serrata]]<ref>{{cite journal |last1=Ahangarpour |first1=Akram |last2=Heidari |first2=Hamid |last3=Fatemeh |first3=Ramezani Ali Akbari |last4=Pakmehr |first4=Mostafa |last5=Shahbazian |first5=Hajeye |last6=Ahmadi |first6=Iraj |last7=Mombeini |first7=Zahra |last8=Mehrangiz |first8=Babadi Hajani |title=Effect of Boswellia serrata supplementation on blood lipid, hepatic enzymes and fructosamine levels in type2 diabetic patients |journal=Journal of Diabetes and Metabolic Disorders |date=2014 |volume=13 |issue=1 |pages=29 |doi=10.1186/2251-6581-13-29 |pmid=24495344 |pmc=3929136 |language=en |doi-access=free }}</ref>
* [[L-arginine]] may enhance the effects of a Statin, but will not lead to a reduction in cholesterol alone.<ref>{{cite journal |last1=Schulze |first1=Friedrich |last2=Glos |first2=Sabrina |last3=Petruschka |first3=Dörte |last4=Altenburg |first4=Christiane |last5=Maas |first5=Renke |last6=Benndorf |first6=Ralf |last7=Schwedhelm |first7=Edzard |last8=Beil |first8=Ulrich |last9=Böger |first9=Rainer H. |title=L-Arginine enhances the triglyceride-lowering effect of simvastatin in patients with elevated plasma triglycerides |url=https://pubmed.ncbi.nlm.nih.gov/19555809/ |journal=Nutrition Research (New York, N.Y.) |pages=291–297 |doi=10.1016/j.nutres.2009.04.004 |date=May 2009|volume=29 |issue=5 |pmid=19555809 }}</ref>
* [[Flaxseed oil]]<ref>{{cite journal |last1=Kristensen |first1=M |last2=Jensen |first2=MG |last3=Aarestrup |first3=J |last4=Petersen |first4=KE |last5=Søndergaard |first5=L |last6=Mikkelsen |first6=MS |last7=Astrup |first7=A |title=Flaxseed dietary fibers lower cholesterol and increase fecal fat excretion, but magnitude of effect depend on food type. |journal=Nutrition & Metabolism |date=3 February 2012 |volume=9 |pages=8 |doi=10.1186/1743-7075-9-8 |pmid=22305169 |pmc=3307491 |doi-access=free }}</ref>