Editing Jaundice (section)

=== Prehepatic causes ===
Prehepatic jaundice is most commonly caused by a pathological increased rate of red blood cell (erythrocyte) [[hemolysis]]. The increased breakdown of erythrocytes → increased unconjugated serum bilirubin → increased deposition of unconjugated bilirubin into mucosal tissue.<ref>{{cite book | vauthors = Joseph A, Samant H | chapter = Jaundice |date=2022 | chapter-url = http://www.ncbi.nlm.nih.gov/books/NBK544252/ | title = StatPearls |place=Treasure Island (FL) |publisher=StatPearls Publishing |pmid=31334972 |access-date=2022-04-23 }}</ref> These diseases may cause jaundice due to increased erythrocyte hemolysis:<ref>{{cite web |title=What causes jaundice in hemolytic anemia? |url=https://www.medscape.com/answers/201066-27045/what-causes-jaundice-in-hemolytic-anemia |access-date=2022-04-26 |website=www.medscape.com |language=en}}</ref>
* [[Sickle-cell anemia]]<ref>{{cite web|title=What Is Sickle Cell Disease?|url=http://www.nhlbi.nih.gov/health/health-topics/topics/sca|website=National Heart, Lung, and Blood Institute|access-date=8 March 2016|date=12 June 2015|url-status=live|archive-url=https://web.archive.org/web/20160306021706/http://www.nhlbi.nih.gov/health/health-topics/topics/sca/|archive-date=6 March 2016}}</ref>
* [[Spherocytosis]]<ref>{{cite book| vauthors = Hillman RS, Ault KA, Rinder HM |title=Hematology in clinical practice: a guide to diagnosis and management|url=https://books.google.com/books?id=NJs1VpA8SEoC&pg=PA146|accessdate=15 November 2010|year=2005|publisher=McGraw-Hill Professional|isbn=978-0-07-144035-6|pages=146–}}</ref>
* [[Thalassemia]]<ref>{{cite web |url=https://www.lecturio.com/concepts/thalassemia/ | title= Thalassemia
|website=The Lecturio Medical Concept Library |access-date= 27 July 2021}}</ref>
* [[Pyruvate kinase deficiency]]
* [[Glucose-6-phosphate dehydrogenase deficiency]]
* [[Microangiopathic hemolytic anemia]]
* [[Hemolytic–uremic syndrome]]
* Severe [[malaria]] (in endemic countries)