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Infectious mononucleosis
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===Adolescents and young adults=== In [[adolescence]] and young adulthood, the disease presents with a characteristic triad:<ref name=Cohen2005>{{cite book|last=Cohen|first=Jeffrey I.|title=Epstein-Barr Virus|year=2005|publisher=Horizon Scientific Press|isbn=978-1-904455-03-5|pages=35β42|chapter-url=https://books.google.com/books?id=TRO-wXto8hcC&q=epstein-barr+jeffrey+I.+cohen+abstract|editor=Robertson, Erle S.|access-date=18 June 2013|chapter=Clinical Aspects of Epstein-Barr Infection|url-status=live|archive-url=https://web.archive.org/web/20140224131627/http://books.google.com/books?id=TRO-wXto8hcC&printsec=frontcover#v=onepage&q=epstein-barr%20jeffrey%20I.%20cohen%20abstract&f=false|archive-date=24 February 2014}}</ref> * [[Fever]] β usually lasting 14 days;<ref>{{cite book|last1=Cohen|first1=Jonathan|last2=Powderly|first2=William G.|last3=Opal|first3=Steven M.|title=Infectious Diseases|date=2016|publisher=Elsevier Health Sciences|isbn=978-0-7020-6338-1|page=79|url=https://books.google.com/books?id=Dhq3DAAAQBAJ&pg=PA79|language=en|url-status=live|archive-url=https://web.archive.org/web/20170911003200/https://books.google.com/books?id=Dhq3DAAAQBAJ&pg=PA79|archive-date=2017-09-11}}</ref> often mild.<ref name=Harrison/> * [[acute pharyngitis|Sore throat]] β usually severe for 3β5 days, before resolving in the next 7β10 days.<ref>{{cite book|last1=Bennett|first1=John E.|last2=Dolin|first2=Raphael|last3=Blaser|first3=Martin J.|title=Principles and Practice of Infectious Diseases|date=2014|publisher=Elsevier Health Sciences|isbn=978-1-4557-4801-3|page=1760|url=https://books.google.com/books?id=BseNCgAAQBAJ&pg=PA1760|language=en|url-status=live|archive-url=https://web.archive.org/web/20170911003200/https://books.google.com/books?id=BseNCgAAQBAJ&pg=PA1760|archive-date=2017-09-11}}</ref> * [[lymphadenopathy|Swollen glands]] β mobile; usually located around the back of the neck (posterior [[cervical lymph nodes]]) and sometimes throughout the body.<ref name=JAMA2016/><ref name=Harrison/><ref name="Benign lymphadenopathy">{{cite journal |last1=Weiss |first1=LM|last2=O'Malley|first2=D|title=Benign lymphadenopathies|journal=Modern Pathology|volume=26 |issue=Supplement 1 |pages=S88βS96 |year=2013|pmid=23281438|doi=10.1038/modpathol.2012.176|doi-access=free}}</ref> Another major symptom is [[Fatigue (medical)|feeling tired]].<ref name=CDC2014Eb/> [[Headache]]s are common, and [[abdominal pain]]s with [[nausea]] or [[vomiting]] sometimes also occur.<ref name=Cohen2005/> Symptoms most often disappear after about 2β4 weeks.<ref name=CDC2014Eb/><ref name=Johannsen2009/> However, fatigue and a general feeling of being unwell ([[malaise]]) may sometimes last for months.<ref name=Harrison/> Fatigue lasts more than one month in an estimated 28% of cases.<ref>{{cite book|last1=Robertson|first1=Erle S.|title=Epstein-Barr Virus|date=2005|publisher=Horizon Scientific Press|isbn=978-1-904455-03-5|page=36|url=https://books.google.com/books?id=TRO-wXto8hcC&pg=PA36|language=en|url-status=live|archive-url=https://web.archive.org/web/20170911003200/https://books.google.com/books?id=TRO-wXto8hcC&pg=PA36|archive-date=2017-09-11}}</ref> Mild fever, swollen neck glands and [[Myalgia|body aches]] may also persist beyond 4 weeks.<ref name=Harrison/><ref name=Luzuriaga2010>{{cite journal|last=Luzuriaga|first=K|author2=Sullivan, JL|title=Infectious mononucleosis|journal=The New England Journal of Medicine|date=May 27, 2010|volume=362|issue=21|pages=1993β2000|pmid=20505178|doi=10.1056/NEJMcp1001116}}</ref><ref name=Ebell2004/> Most people are able to resume their usual activities within 2β3 months.<ref name=Luzuriaga2010/> The most prominent sign of the disease is often [[pharyngitis]], which is frequently accompanied by [[tonsillitis|enlarged tonsils]] with [[pus]]βan [[exudate]] similar to that seen in cases of [[strep throat]].<ref name=Harrison/> In about 50% of cases, small reddish-purple spots called [[petechia]]e can be seen on the [[roof of the mouth]].<ref name=Ebell2004>{{cite journal | author = Ebell MH | title = Epstein-Barr virus infectious mononucleosis | journal = American Family Physician | volume = 70 | issue = 7 | pages = 1279β87 |date=November 2004| pmid = 15508538}}</ref> Palatal [[enanthem]] can also occur, but is relatively uncommon.<ref name=Harrison/> A small minority of people spontaneously present a [[rash]], usually on the arms or trunk, which can be [[macular]] ([[morbilliform]]) or [[papule|papular]].<ref name=Harrison/> Almost all people given [[amoxicillin]] or [[ampicillin]] eventually develop a generalized, itchy maculopapular rash, which however does not imply that the person will have [[adverse reaction]]s to [[penicillin]]s again in the future.<ref name=Harrison/><ref name=Johannsen2009>{{cite book|last=Johannsen|first=EC|title=Mandell, Douglas, and Bennett's principles and practice of infectious disease|year=2009|publisher=Churchill Livingstone|location=Philadelphia|isbn=978-0-443-06839-3|edition=7th|author2=Kaye, KM|editor=Mandell, GL |editor2=Bennett, JE |editor3=Dolin, R|chapter=Epstein-Barr virus (infectious mononucleosis, Epstein-Barr virus-associated malignant disease, and other diseases)}}</ref> Occasional cases of [[erythema nodosum]] and [[erythema multiforme]] have been reported.<ref name=Harrison/> Seizures may also occasionally occur.<ref>{{cite book|last1=Shorvon|first1=Simon D.|last2=Andermann|first2=Frederick|last3=Guerrini|first3=Renzo|title=The Causes of Epilepsy: Common and Uncommon Causes in Adults and Children|date=2011|publisher=Cambridge University Press|isbn=978-1-139-49578-3|page=470|url=https://books.google.com/books?id=BUs-AYMBbC0C&pg=PA470|language=en|url-status=live|archive-url=https://web.archive.org/web/20180104013750/https://books.google.ca/books?id=BUs-AYMBbC0C&pg=PA470|archive-date=2018-01-04}}</ref>
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