Editing Flaviviridae (section)

== Life cycle ==
[[File:Pathogens-07-00068-g002.webp|thumb|Life cycle of [[Japanese encephalitis virus]] (JEV)]]
Viral replication is cytoplasmic. Entry into the host cell is achieved by attachment of the viral envelope protein E to host receptors, which mediates [[clathrin]]-mediated endocytosis. Replication follows the positive-stranded RNA virus replication model. Positive-stranded RNA virus transcription is the method of transcription. Translation takes place by viral initiation. The virion assembles by budding through intracellular membranes and exits the host cell by exocytosis.<ref name="ICTVReport" /><ref name="ViralZone" /><ref>{{cite journal|vauthors=Simmonds P, Becher P, Bukh J, Gould EA, Meyers G, Monath T, Muerhoff S, Pletnet A, Rico-Hesse R, Smith DB, Stapleton JT, ((ICTV Report Consortium))|title=ICTV Virus Taxonomy Profile: ''Flaviviridae''|journal=Journal of General Virology|year=2017|volume=98|issue=1|pages=2–3|doi=10.1099/jgv.0.000672|pmid=28218572|pmc=5370391|doi-access=free}}</ref>

{| class="wikitable sortable collapsible collapsed" style="text-align:center"
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! Genus !! Host details !! Tissue tropism !! Entry details !! Release details !! Replication site !! Assembly site !! Transmission
|-
|''Flavivirus''||Humans; mammals; mosquitoes; ticks||Epithelium: skin; epithelium: kidney; epithelium: intestine; epithelium: testes||Clathrin-mediated endocytosis||Secretion||Cytoplasm||Cytoplasm||Zoonosis; arthropod bite
|-
|''Hepacivirus''||Humans||Epithelium: skin; epithelium: kidney; epithelium: intestine; epithelium: testes||Clathrin-mediated endocytosis||Secretion||Cytoplasm||Cytoplasm||Sex; blood
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|''Pegivirus''||Mammals||None||Clathrin-mediated endocytosis||Secretion||Cytoplasm||Cytoplasm||Unknown
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|''Pestivirus''||Mammals||None||Clathrin-mediated endocytosis||Secretion||Cytoplasm||Cytoplasm||Vertical: parental
|}