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==Structure and function== [[File:Gene structure.svg|frame|right|Exons in a messenger RNA precursor (pre-mRNA). Exons can include both sequences that code for amino acids (red) and untranslated sequences (grey). Introns β those parts of the pre-mRNA that are not in the mRNA β (blue) are removed, and the exons are joined (spliced) to form the final functional mRNA. The 5β² and 3β² ends of the mRNA are marked to differentiate the two untranslated regions (grey).]] In protein-coding genes, the exons include both the protein-coding sequence and the 5β²- and 3β²-[[untranslated region]]s (UTR). Often the first exon includes both the 5β²-UTR and the first part of the coding sequence, but exons containing only regions of 5β²-UTR or (more rarely) 3β²-UTR occur in some genes, i.e. the UTRs may contain introns.<ref>{{cite journal|last1=Bicknell|first1=AA|s2cid=5808466|title=Introns in UTRs: Why we should stop ignoring them.|journal=BioEssays|date=December 2012|volume=34|issue=12|pages=1025β1034|doi=10.1002/bies.201200073|pmid=23108796|doi-access=free}}</ref> Some [[non-coding RNA]] transcripts also have exons and introns. Mature mRNAs originating from the same gene need not include the same exons, since different introns in the pre-mRNA can be removed by the process of [[alternative splicing]]. Exonization is the creation of a new exon, as a result of mutations in [[introns]].<ref>{{cite journal |author=Sorek R |title=The birth of new exons: mechanisms and evolutionary consequences |journal=RNA |volume=13 |issue=10 |pages=1603β8 |date=October 2007 |pmid=17709368 |pmc=1986822 |doi=10.1261/rna.682507}}</ref>
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