Editing Dwarfism (section)

===Achondroplasia===
{{further|Achondroplasia}}
The most recognizable and most common form of dwarfism in humans is achondroplasia, which accounts for 70% of dwarfism cases, and occurs in 4 to 15 out of 100,000 live births.<ref name="Çevik-2010">{{Cite journal|last1=Çevik|first1=Banu|last2=Çolakoğlu|first2=Serhan|url=http://www.meja.aub.edu.lb/downloads/20_6/907.pdf|title=Anesthetic management of achondroplastic dwarf undergoing cesarean section|journal=M.E.J. Anesth.|volume=20|issue=6|year=2010|archive-url=https://web.archive.org/web/20180713022612/http://www.meja.aub.edu.lb/downloads/20_6/907.pdf|url-status=dead|archive-date=July 13, 2018}}</ref>

It produces [[Rhizomelia|rhizomelic]] short limbs, increased spinal curvature, and distortion of skull growth. In achondroplasia the body's limbs are proportionately shorter than the trunk (abdominal area), with a larger head than average and characteristic facial features. Achondroplasia is an [[autosomal dominant]] disorder caused by the presence of an altered [[allele]] in the genome. If a pair of achondroplasia alleles are present, the result is fatal, usually perinatally. Achondroplasia is a mutation in the [[fibroblast growth factor receptor 3]].<ref>{{Gene|FGFR3}}</ref> In the context of achondroplasia, this mutation causes FGFR3 to become constitutively active, inhibiting bone growth.<ref>{{cite web |url=http://ghr.nlm.nih.gov/condition=achondroplasia |title=Achondroplasia – Genetics Home Reference |date=2008-09-26|work=Genetics Home Reference|publisher=National Institute of Health |access-date=2008-10-01}}</ref>