Editing Dendritic cell (section)

===''In vivo'' – primate===
{{main|Plasmacytoid dendritic cell}}
The most common division of dendritic cells is '''conventional dendritic cells''' (a.k.a. '''myeloid dendritic cells''') vs. [[plasmacytoid dendritic cell]] (most likely of [[Lymphopoiesis#Lymphopoiesis for dendritic cells|lymphoid]] lineage) as described in the table below:

{| class="wikitable"
!width=30%| Name 
!width=30%| Description 
!width=25%| Secretion
!width=15%| [[Toll-like receptor]]s <ref>{{cite journal |vauthors=Sallusto F, Lanzavecchia A |title=The instructive role of dendritic cells on T-cell responses |journal=Arthritis Res. |volume=4 |issue= Suppl 3|pages=S127–32 |year=2002 |pmid=12110131 |doi=10.1186/ar567 |pmc=3240143 |doi-access=free }}</ref>
|-
| Conventional dendritic cell (cDC)<br>(previously called ''myeloid dendritic cell'' (mDC)) 
|| Most similar to [[monocyte]]s. mDC are made up of at least two subsets:
# cDC-1, which is a major stimulator of cytotoxic T cells
#cDC-2, which stimulates helper T cells
|| [[Interleukin 12]] (IL-12), [[Interleukin 6]] (IL-6), TNF, chemokines 
|| [[TLR 2]], [[TLR 4]]
|-
|| Plasmacytoid dendritic cell (pDC) 
|| Look like [[plasma cell]]s, but have certain characteristics similar to myeloid dendritic cells.<ref>{{cite journal |vauthors=McKenna K, Beignon A, Bhardwaj N |title=Plasmacytoid Dendritic Cells: Linking Innate and Adaptive Immunity |journal=[[Journal of Virology|J. Virol.]] |volume=79 |issue=1 |pages=17–27 |year=2005 |pmid=15596797 |doi=10.1128/JVI.79.1.17-27.2005 |pmc=538703}}</ref>   
|| Can produce high amounts of [[interferon|interferon-α]]<ref name="pmid12953097">{{cite journal  |vauthors=Vanbervliet B, Bendriss-Vermare N, Massacrier C, etal |title=The Inducible CXCR3 Ligands Control Plasmacytoid Dendritic Cell Responsiveness to the Constitutive Chemokine Stromal Cell–derived Factor 1 (SDF-1)/CXCL12 |journal=J. Exp. Med. |volume=198 |issue=5 |pages=823–30 |date=September 2003 |pmid=12953097 |pmc=2194187 |doi=10.1084/jem.20020437 }}</ref> and were previously called ''interferon-producing cells''.<ref>{{cite journal |author=Liu YJ |title=IPC: professional type 1 interferon-producing cells and plasmacytoid dendritic cell precursors |journal=Annu. Rev. Immunol. |volume=23 |issue= 1|pages=275–306 |year=2005 |pmid=15771572 |doi=10.1146/annurev.immunol.23.021704.115633}}</ref> || [[TLR 7]], [[TLR 9]]
|}

The markers [[BDCA-2]], [[BDCA-3]], and [[BDCA-4]] can be used to discriminate among the types.<ref>{{cite journal |vauthors=Dzionek A, Fuchs A, Schmidt P, Cremer S, Zysk M, Miltenyi S, Buck D, Schmitz J |title=BDCA-2, BDCA-3, and BDCA-4: three markers for distinct subsets of dendritic cells in human peripheral blood |journal=J Immunol |volume=165 |issue=11 |pages=6037–46 |year=2000 |pmid=11086035 |url=http://www.jimmunol.org/cgi/reprint/165/11/6037.pdf |doi=10.4049/jimmunol.165.11.6037|s2cid=22459468 |doi-access=free }}</ref>

[[File:Centrocyte, centroblast and follicular dendritic cell in a follicular lymphoma.jpg|thumb|Histologic comparison of cell types in a [[germinal center]], including follicular dendritic cells, H&E stain:<br>- '''[[Centrocyte]]s''' are small to medium size with angulated, elongated, cleaved, or twisted nuclei.<br>- '''[[Centroblast]]s''' are larger cells containing vesicular nuclei with one to three basophilic nucleoli apposing the nuclear membrane.<br>- '''[[Follicular dendritic cell]]s''' have round nuclei, centrally located nucleoli, bland and dispersed chromatin, and flattening of adjacent nuclear membrane.]]

Lymphoid and myeloid DCs evolve from lymphoid and myeloid precursors, respectively, and thus are of [[hematopoietic]] origin. By contrast, [[follicular dendritic cells]] (FDC) are probably of [[mesenchymal]] rather than [[hematopoietic]] origin and do not express [[MHC class II]], but are so named because they are located in lymphoid follicles and have long "dendritic" processes.