Editing DNA vaccine (section)

== Advantages ==

* No risk for infections<ref name="Robinson2000" />
* Antigen presentation by both [[MHC class I]] and [[MHC class II|class II]] molecules<ref name="Robinson2000" />
* Polarise T-cell response toward type 1 or type 2<ref name="Robinson2000" />
* Immune response focused on the antigen of interest
* Ease of development and production<ref name="Robinson2000" />
* Stability for storage and shipping
* Cost-effectiveness
* Obviates need for peptide synthesis, expression and purification of recombinant proteins and use of toxic adjuvants<ref name="Sedegah1994">{{cite journal | vauthors = Sedegah M, Hedstrom R, Hobart P, Hoffman SL | title = Protection against malaria by immunization with plasmid DNA encoding circumsporozoite protein | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 91 | issue = 21 | pages = 9866–9870 | date = October 1994 | pmid = 7937907 | pmc = 44918 | doi = 10.1073/pnas.91.21.9866 | doi-access = free | bibcode = 1994PNAS...91.9866S | jstor = 2365723 }}</ref>
* Long-term persistence of immunogen<ref name="Alarcon1999" />
* ''In vivo'' expression ensures protein more closely resembles normal eukaryotic structure, with accompanying post-translational modifications<ref name="Alarcon1999" />