Editing Cytochrome c oxidase (section)

=== The conserved subunits ===
{| border=1 class="wikitable" style="text-align:center"
|+ Table of conserved subunits of cytochrome c oxidase complex<ref name="pmid9565029">{{cite journal | vauthors = Zhang Z, Huang L, Shulmeister VM, Chi YI, Kim KK, Hung LW, Crofts AR, Berry EA, Kim SH | title = Electron transfer by domain movement in cytochrome bc1 | journal = Nature | volume = 392 | issue = 6677 | pages = 677–84 | date = April 1998 | pmid = 9565029 | doi = 10.1038/33612 | bibcode = 1998Natur.392..677Z | s2cid = 4380033 }}</ref><ref name="pmid21211513">{{cite journal | vauthors = Kaila VR, Oksanen E, Goldman A, Bloch DA, Verkhovsky MI, Sundholm D, Wikström M | title = A combined quantum chemical and crystallographic study on the oxidized binuclear center of cytochrome c oxidase | journal = Biochimica et Biophysica Acta (BBA) - Bioenergetics | volume = 1807 | issue = 7 | pages = 769–78 | date = July 2011 | pmid = 21211513 | doi = 10.1016/j.bbabio.2010.12.016 | doi-access = free }}</ref>
!'''No.'''
!Subunit name
![[Human]] protein
!Protein description from [[UniProt]]
![[Pfam]] family with Human protein
|-
| 1 || Cox1 || [[MT-CO1|COX1_HUMAN]] || Cytochrome c oxidase subunit 1  || {{Pfam|PF00115}}
|-
| 2 || Cox2 || [[MT-CO2|COX2_HUMAN]] || Cytochrome c oxidase subunit 2 || {{Pfam|PF02790}}, {{Pfam|PF00116}}
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| 3 || Cox3 || [[MT-CO3|COX3_HUMAN]] || Cytochrome c oxidase subunit 3 || {{Pfam|PF00510}}
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| 4 || Cox4i1 || [[COX4I1|COX41_HUMAN]] || Cytochrome c oxidase subunit 4 isoform 1, mitochondrial || {{Pfam|PF02936}}
|-
| 5 || Cox4a2  || [[COX4I2|COX42_HUMAN]] || Cytochrome c oxidase subunit 4 isoform 2, mitochondrial || {{Pfam|PF02936}}
|-
| 6 || Cox5a || [[COX5A| COX5A_HUMAN ]] || Cytochrome c oxidase subunit 5A, mitochondrial || {{Pfam|PF02284}}
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| 7 || Cox5b || [[COX5B| COX5B_HUMAN ]] || Cytochrome c oxidase subunit 5B, mitochondrial || {{Pfam|PF01215}}
|-
| 8 || Cox6a1  || [[COX6A1|CX6A1_HUMAN]] ||  Cytochrome c oxidase subunit 6A1, mitochondrial || {{Pfam|PF02046}}
|-
| 9 || Cox6a2  || [[COX6A2|CX6A2_HUMAN]] ||   Cytochrome c oxidase subunit 6A2, mitochondrial || {{Pfam|PF02046}}
|-
| 10 || Cox6b1  || [[COX6B1|CX6B1_HUMAN]] ||   Cytochrome c oxidase subunit 6B1   || {{Pfam|PF02297}}
|-
| 11 || Cox6b2  || [[COX6B2|CX6B2_HUMAN]] ||  Cytochrome c oxidase subunit 6B2 || {{Pfam|PF02297}}
|-
| 12 || Cox6c  || [[COX6C| COX6C_HUMAN]]|| Cytochrome c oxidase subunit 6C || {{Pfam|PF02937}}
|-
| 13 || Cox7a1  || [[COX7A1|CX7A1_HUMAN]] ||  Cytochrome c oxidase subunit 7A1, mitochondrial || {{Pfam|PF02238}}
|-
| 14 || Cox7a2  || [[COX7A2|CX7A2_HUMAN]] ||  Cytochrome c oxidase subunit 7A2, mitochondrial || {{Pfam|PF02238}}
|-
| 15 || Cox7a3  || [[COX7A2P2|COX7S_HUMAN]] ||  Putative cytochrome c oxidase subunit 7A3, mitochondrial || {{Pfam|PF02238}}
|-
| 16 ||  Cox7b  || [[COX7B| COX7B_HUMAN]]|| Cytochrome c oxidase subunit 7B, mitochondrial || {{Pfam|PF05392}}
|-
| 17 ||  Cox7c  || [[COX7C| COX7C_HUMAN]]|| Cytochrome c oxidase subunit 7C, mitochondrial || {{Pfam|PF02935}}
|-
| 18 || Cox7r  || [[COX7A2L|COX7R_HUMAN]] ||   Cytochrome c oxidase subunit 7A-related protein, mitochondrial || {{Pfam|PF02238}}
|-
| 19 || Cox8a  || [[COX8A| COX8A_HUMAN]]|| Cytochrome c oxidase subunit 8A, mitochondrial P || {{Pfam|PF02285}}
|-
| 20 ||  Cox8c || [[COX8C| COX8C_HUMAN]]|| Cytochrome c oxidase subunit 8C, mitochondrial ||  {{Pfam|PF02285}}
|-
|-
|'''Assembly subunits'''<ref name="pmid22356826">{{cite journal | vauthors = Szklarczyk R, Wanschers BF, Cuypers TD, Esseling JJ, Riemersma M, van den Brand MA, Gloerich J, Lasonder E, van den Heuvel LP, Nijtmans LG, Huynen MA | title = Iterative orthology prediction uncovers new mitochondrial proteins and identifies C12orf62 as the human ortholog of COX14, a protein involved in the assembly of cytochrome c oxidase | journal = Genome Biology | volume = 13 | issue = 2 | pages = R12 | date = February 2012 | pmid = 22356826 | pmc = 3334569 | doi = 10.1186/gb-2012-13-2-r12 | doi-access = free }}</ref><ref name="pmid23260140">{{cite journal | vauthors = Mick DU, Dennerlein S, Wiese H, Reinhold R, Pacheu-Grau D, Lorenzi I, Sasarman F, Weraarpachai W, Shoubridge EA, Warscheid B, Rehling P | title = MITRAC links mitochondrial protein translocation to respiratory-chain assembly and translational regulation | journal = Cell | volume = 151 | issue = 7 | pages = 1528–41 | date = December 2012 | pmid = 23260140 | doi = 10.1016/j.cell.2012.11.053 | doi-access = free | hdl = 11858/00-001M-0000-000E-DDDF-4 | hdl-access = free }}</ref><ref name="pmid24333015">{{cite journal | vauthors = Kozjak-Pavlovic V, Prell F, Thiede B, Götz M, Wosiek D, Ott C, Rudel T | title = C1orf163/RESA1 is a novel mitochondrial intermembrane space protein connected to respiratory chain assembly | journal = Journal of Molecular Biology | volume = 426 | issue = 4 | pages = 908–20 | date = February 2014 | pmid = 24333015 | doi = 10.1016/j.jmb.2013.12.001 }}</ref>
|-
|-
| 1 || Coa1 ||  [[COA1| COA1_HUMAN ]] || Cytochrome c oxidase assembly factor 1 homolog  ||  {{Pfam|PF08695}}
|-
| 2 || Coa3 ||  [[COA3| COA3_HUMAN ]] || Cytochrome c oxidase assembly factor 3 homolog, mitochondrial  ||  {{Pfam|PF09813}}
|-
| 3 || Coa4 ||  [[COA4| COA4_HUMAN ]] || Cytochrome c oxidase assembly factor 4 homolog, mitochondrial  ||  {{Pfam|PF06747}}
|-
| 4 || Coa5 ||  [[COA5| COA5_HUMAN ]] || Cytochrome c oxidase assembly factor 5 ||  {{Pfam|PF10203}}
|-
| 5 || Coa6 ||  [[COA6| COA6_HUMAN ]] || Cytochrome c oxidase assembly factor 6 homolog    ||  {{Pfam|PF02297}}
|-
| 6 || Coa7 ||  [[COA7| COA7_HUMAN ]] || Cytochrome c oxidase assembly factor 7, ||  {{Pfam|PF08238}}
|-
| 7 || Cox11 ||  [[COX11| COX11_HUMAN ]] || Cytochrome c oxidase assembly protein COX11 mitochondrial ||  {{Pfam|PF04442}}
|-
| 8 || Cox14 ||  [[COX14| COX14_HUMAN ]] || Cytochrome c oxidase assembly protein ||  {{Pfam|PF14880}}
|-
| 9 || Cox15 ||  [[COX15| COX15_HUMAN ]] || Cytochrome c oxidase assembly protein COX15 homolog ||  {{Pfam|PF02628}}
|-
| 10 || Cox16 ||  [[COX16| COX16_HUMAN ]] || Cytochrome c oxidase assembly protein COX16 homolog mitochondrial ||  {{Pfam|PF14138}}
|-
| 11 || Cox17 ||  [[COX17| COX17_HUMAN ]] || Cytochrome c oxidase copper chaperone ||  {{Pfam|PF05051}}
|-
| 12 || Cox18<ref name="pmid16911509">{{cite journal | vauthors = Gaisne M, Bonnefoy N | title = The COX18 gene, involved in mitochondrial biogenesis, is functionally conserved and tightly regulated in humans and fission yeast | journal = FEMS Yeast Research | volume = 6 | issue = 6 | pages = 869–82 | date = September 2006 | pmid = 16911509 | doi = 10.1111/j.1567-1364.2006.00083.x | doi-access = free }}</ref> ||  [[COX18| COX18_HUMAN ]] || Mitochondrial inner membrane protein (Cytochrome c oxidase assembly protein 18) ||  {{Pfam|PF02096}}
|-
| 13 || Cox19 ||  [[COX19| COX19_HUMAN ]] || Cytochrome c oxidase assembly protein ||  {{Pfam|PF06747}}
|-
| 14 || Cox20 ||  [[COX20| COX20_HUMAN ]] || Cytochrome c oxidase protein 20 homolog ||  {{Pfam|PF12597}}
|-
|}