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Coxsackie A virus
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==Diseases== [[File:Coxsackievirus infection on skin.jpg|thumb|Coxsackievirus infection on skin of adult]] The most well known Coxsackie A disease is [[hand, foot and mouth disease]] (unrelated to [[foot-and-mouth disease]]), a common childhood illness which affects mostly children aged 5 or under,<ref>{{cite web | url = http://www.sarawak.health.gov.my/hfmd.htm | title = Hand, Foot, & Mouth Disease | archive-url = https://web.archive.org/web/20080512224239/http://www.sarawak.health.gov.my/hfmd.htm | archive-date = 2008-05-12 | work = Sarawak }}</ref> often produced by Coxsackie A16. In most individuals, infection is [[asymptomatic]] or causes only mild symptoms. In others, infection produces short-lived (7β10 days) [[fever]] and painful [[blister]]s in the mouth (a condition known as ''[[herpangina]]''), on the palms and fingers of the hand, or on the soles of the feet. There can also be blisters in the throat, or on or above the [[tonsil]]s. Adults can also be affected. The rash, which can appear several days after high temperature and painful sore throat, can be itchy and painful, especially on the hands/fingers and bottom of feet.<ref name="CDC_Symptoms" /> Other diseases include acute haemorrhagic [[conjunctivitis]] (A24 specifically), herpangina, and aseptic [[meningitis]] (both Coxsackie A and B viruses). Coxsackievirus A7 is associated with neurological diseases and can cause paralytic poliomyelitis.<ref>{{cite journal | vauthors = Yamayoshi S, Iizuka S, Yamashita T, Minagawa H, Mizuta K, Okamoto M, Nishimura H, Sanjoh K, Katsushima N, Itagaki T, Nagai Y, Fujii K, Koike S | display-authors = 6 | title = Human SCARB2-dependent infection by coxsackievirus A7, A14, and A16 and enterovirus 71 | journal = Journal of Virology | volume = 86 | issue = 10 | pages = 5686β96 | date = May 2012 | pmid = 22438546 | pmc = 3347270 | doi = 10.1128/JVI.00020-12 }}</ref>
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