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=== Classification === [[File:Oleandrin.svg|thumb|class=skin-invert-image|Example of the chemical structure of [[oleandrin]], a potent toxic cardiac glycoside extracted from the [[Oleander]] bush.]] Cardiac glycosides can be more specifically categorized based on the plant they are derived from, as in the following list. For example, cardenolides have been primarily derived from the foxglove plants ''[[Digitalis purpurea]]'' and ''[[Digitalis lanata]]'', while bufadienolides have been derived from the venom of the [[cane toad]] ''Rhinella marina'' (formerly known as ''Bufo marinus''), from which they receive the "bufo" portion of their name.<ref name=EmedPoison>{{Cite journal|date=2017-05-05|title=Cardiac Glycoside Plant Poisoning: Practice Essentials, Pathophysiology, Etiology|url=http://emedicine.medscape.com/article/816781-overview |website=Medscape |publisher=WebMD}}</ref> Below is a list of organisms from which cardiac glycosides can be derived. ==== Plant cardenolides ==== * ''[[Lily of the valley|Convallaria majalis]]'' (Lily of the Valley): [[convallatoxin]]<ref name=pharmacognosy>{{Cite web|url=http://www.tankonyvtar.hu/en/tartalom/tamop412A/2011-0016_08_pharmacognosy_2/ch05s05.html|title=Pharmacognosy 2{{!}}Digital Textbook Library|website=www.tankonyvtar.hu|language=en-US|access-date=2017-06-08}}</ref> * ''[[Antiaris toxicaria]]'' (upas tree): [[antiarin]] * ''[[Strophanthus kombe]]'' (''Strophanthus'' vine): [[ouabain]] (g-strophanthin) and other [[strophanthin]]s * ''[[Digitalis lanata]]'' and ''[[Digitalis purpurea]]'' (Woolly and purple foxglove): [[digoxin]], [[digitoxin]] * ''[[Nerium oleander]]'' (oleander tree): [[oleandrin]] * ''[[Asclepias]] sp.'' (milkweed): asclepin, calotropin, uzarin, calactin, coroglucigenin, uzarigenin, oleandrin * ''[[Adonis vernalis]]'' (Spring pheasant's eye): [[adonitoxin]] * ''[[Kalanchoe daigremontiana]]'' and other ''[[Kalanchoe]]'' species: [[daigremontianin]] * ''[[Erysimum cheiranthoides]]'' (wormseed wallflower) and other ''[[Erysimum]]'' species<ref>{{cite journal | vauthors = Züst T, Strickler SR, Powell AF, Mabry ME, An H, Mirzaei M, York T, Holland CK, Kumar P, Erb M, Petschenka G, Gómez JM, Perfectti F, Müller C, Pires JC, Mueller LA, Jander G | display-authors = 6 | title = Independent evolution of ancestral and novel defenses in a genus of toxic plants (''Erysimum'', Brassicaceae) | journal = eLife | volume = 9 | pages = 761569 | date = April 2020 | pmid = 32252891 | doi = 10.7554/eLife.51712|biorxiv=10.1101/761569 | pmc = 7180059 | doi-access = free }}</ref> * ''[[Cerbera odollam]]'' (suicide tree): [[cerberin]] * ''[[Periploca (plant)|Periploca sepium]]: [[periplocin]] ==== Other cardenolides ==== * some species of [[Chrysolina|Chrysolina beetles]], including ''Chrysolina coerulans'', have cardiac glycosides (based on the unusual sugar [[xylose]]) in their defensive glands.<ref>{{cite book | chapter = Chapter 7: Higher Terpenes and Steroids: Sterols in Insects | chapter-url = https://books.google.com/books?id=AbXid2E-17YC&pg=PA112 | vauthors = Morgan ED |title=Biosynthesis in insects |date=2004 |publisher=Royal Society of Chemistry |location=Cambridge |isbn=978-0-85404-691-1 | page = 112 }}</ref> ==== Bufadienolide class compounds ==== * ''[[Leonurus cardiaca]]'' (motherwort): [[scillarenin]]<ref name=pharmacognosy/> * ''[[Drimia maritima]]'' (squill): [[proscillaridine A]] * [[Cane toad|''Rhinella marina'']] (cane toad): various [[bufadienolide]]s – see also [[toad venom]] * ''[[Kalanchoe daigremontiana]]'' and other ''[[Kalanchoe]]'' species: daigremontianin and others * ''[[Hellebore|Helleborus]]'' spp. ([[hellebore]])<ref>{{cite journal | vauthors = Watanabe K, Mimaki Y, Sakagami H, Sashida Y | title = Bufadienolide and spirostanol glycosides from the rhizomes of helleborusorientalis | journal = Journal of Natural Products | volume = 66 | issue = 2 | pages = 236–241 | date = February 2003 | pmid = 12608856 | doi = 10.1021/np0203638 | bibcode = 2003JNAtP..66..236W }}</ref> {{missing information|section| bufanolides without the diene, also a toad thing|date=December 2022}}
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