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===Impaired production=== * Disturbance of proliferation and differentiation of stem cells ** [[Pure red cell aplasia]]<ref name=Robbins12-1>Table 12-1 in: {{cite book | last1 = Mitchell | first1 = Richard Sheppard | last2 = Kumar | first2 = Vinay | last3 = Abbas | first3 = Abul K. | last4 = Fausto | first4 = Nelson | title = Robbins Basic Pathology | publisher = Saunders | location=Philadelphia |year= 2007|isbn=978-1-4160-2973-1 | edition = 8th}}</ref> ** [[Aplastic anemia]]<ref name=Robbins12-1/> affects all kinds of [[blood cell]]s. [[Fanconi anemia]] is a hereditary disorder or defect featuring aplastic anemia and various other abnormalities. ** Anemia of [[kidney failure]]<ref name=Robbins12-1/> due to insufficient production of the [[hormone]] [[erythropoietin]] ** Anemia of [[endocrine disease]]<ref>{{cite book|last1=Gregg|first1=XT|last2=Prchal|first2=JT|title=Williams Hermatology|date=2007|publisher=McGraw-Hill|chapter=Anemia of Endocrine Disorders}}</ref> * Disturbance of proliferation and maturation of [[erythroblast]]s ** [[Pernicious anemia]]<ref name=Robbins12-1/> is a form of [[megaloblastic anemia]] due to [[vitamin B12 deficiency|vitamin B<sub>12</sub> deficiency]] dependent on impaired absorption of [[Vitamin B12|vitamin B<sub>12</sub>]]. Lack of dietary B<sub>12</sub> causes non-pernicious megaloblastic anemia. ** Anemia of [[folic acid deficiency|folate deficiency]],<ref name=Robbins12-1/> as with vitamin B<sub>12</sub>, causes [[megaloblastic anemia]] ** [[Anemia of prematurity]], by diminished erythropoietin response to declining [[hematocrit]] levels, combined with blood loss from laboratory testing, generally occurs in premature infants at two to six weeks of age. ** Iron-deficiency anemia, resulting in deficient heme synthesis<ref name=Robbins12-1/> ** [[Thalassemia]]s, causing deficient globin synthesis<ref name=Robbins12-1/> ** [[Congenital dyserythropoietic anemia]]s, causing ineffective erythropoiesis ** Anemia of kidney failure<ref name=Robbins12-1/> (also causing stem cell dysfunction) * Other mechanisms of impaired RBC production ** [[Myelophthisic anemia]]<ref name=Robbins12-1/> or [[myelophthisis]] is a severe type of anemia resulting from the replacement of bone marrow by other materials, such as malignant tumors, fibrosis, or granulomas. ** [[Myelodysplastic syndrome]]<ref name=Robbins12-1/> ** anemia of [[chronic inflammation]]<ref name=Robbins12-1/> ** Leukoerythroblastic anemia is caused by space-occupying lesions in the [[bone marrow]] that prevent normal production of blood cells.<ref>{{cite web|url=https://www.dictionary.com/browse/leukoerythroblastosis|title=the definition of leukoerythroblastosis|website=www.dictionary.com|language=en|access-date=2018-12-02|archive-date=2 December 2018|archive-url=https://web.archive.org/web/20181202070610/https://www.dictionary.com/browse/leukoerythroblastosis|url-status=dead}}</ref>
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