Editing Anandamide (section)

===Behavior===
Both the [[Cannabinoid receptor 1|CB1]] and [[Cannabinoid receptor 2|CB2]] receptors (the binding site of anandamide) are under research for a possible role in positive and negative interpretation of environment and setting.<ref>{{cite journal | vauthors = Crane NA, Schuster RM, Fusar-Poli P, Gonzalez R | title = Effects of cannabis on neurocognitive functioning: recent advances, neurodevelopmental influences, and sex differences | journal = Neuropsychology Review | volume = 23 | issue = 2 | pages = 117–137 | date = June 2013 | pmid = 23129391 | pmc = 3593817 | doi = 10.1007/s11065-012-9222-1 }}</ref> The binding relationship of anandamide and the CB1/CB2 may affect neurotransmission of dopamine, serotonin, GABA, and glutamate.<ref>{{cite journal | vauthors = Fantegrossi WE, Wilson CD, Berquist MD | title = Pro-psychotic effects of synthetic cannabinoids: interactions with central dopamine, serotonin, and glutamate systems | journal = Drug Metabolism Reviews | volume = 50 | issue = 1 | pages = 65–73 | date = February 2018 | pmid = 29385930 | pmc = 6419500 | doi = 10.1080/03602532.2018.1428343 }}</ref>

[[Endocannabinoid]]s may disturb [[homeostasis]] in several ways: by enhancing  [[appetite|hunger sensations]], encouraging increased [[food intake]], and shifting [[energy balance (biology)|energy balance]] towards [[lipogenesis|energy storage]]. A resultant decrease in energy expenditure is observed.<ref>{{cite journal | vauthors = Schulz P, Hryhorowicz S, Rychter AM, Zawada A, Słomski R, Dobrowolska A, Krela-Kaźmierczak I | title = What Role Does the Endocannabinoid System Play in the Pathogenesis of Obesity? | journal = Nutrients | volume = 13 | issue = 2 | pages = 373 | date = January 2021 | pmid = 33530406 | pmc = 7911032 | doi = 10.3390/nu13020373 | doi-access = free }}</ref>

Cortical glutamatergic transmission may be modulated by endocannabinoids during stress and fear [[habituation]].<ref>{{cite journal | vauthors = Kamprath K, Plendl W, Marsicano G, Deussing JM, Wurst W, Lutz B, Wotjak CT | title = Endocannabinoids mediate acute fear adaptation via glutamatergic neurons independently of corticotropin-releasing hormone signaling | journal = Genes, Brain and Behavior | volume = 8 | issue = 2 | pages = 203–211 | date = March 2009 | pmid = 19077175 | doi = 10.1111/j.1601-183X.2008.00463.x | s2cid = 21922344 | doi-access = free }}</ref>