Editing 7-Dehydrocholesterol (section)

==Radiation==
Synthesis of pre-vitamin D<sub>3</sub> in the skin involves [[UVB radiation]], which effectively penetrates only the epidermal layers of skin. 7-Dehydrocholesterol absorbs UV light most effectively at [[wavelength]]s between 295 and 300 [[nanometer|nm]] and, thus, the production of vitamin D<sub>3</sub> will occur primarily at those wavelengths.<ref name="pmid6281884">{{cite journal | vauthors = MacLaughlin JA, Anderson RR, Holick MF | title = Spectral character of sunlight modulates photosynthesis of previtamin D3 and its photoisomers in human skin | journal = Science | volume = 216 | issue = 4549 | pages = 1001–3 | date = May 1982 | pmid = 6281884 | doi = 10.1126/science.6281884}}</ref> The two most important factors that govern the generation of pre-vitamin D<sub>3</sub> are the quantity (intensity) and quality (appropriate wavelength) of the UVB irradiation reaching the 7-dehydrocholesterol deep in the stratum basale and stratum spinosum.<ref name = "Norman_1998" /> Light-emitting diodes ([[LED]]s) can be used to produce the radiation.<ref name="pmid28904394">{{cite journal | vauthors = Kalajian TA, Aldoukhi A, Veronikis AJ, Persons K, Holick MF | title = Ultraviolet B Light Emitting Diodes (LEDs) Are More Efficient and Effective in Producing Vitamin D3 in Human Skin Compared to Natural Sunlight | journal = Scientific Reports | volume = 7 | issue = 1 | pages = 11489 | date = September 2017 | pmid = 28904394 | pmc = 5597604 | doi = 10.1038/s41598-017-11362-2}}</ref>

Another important consideration is the quantity of 7-dehydrocholesterol present in the skin. Under normal circumstances, ample quantities of 7-dehydrocholesterol (about 25&ndash;50 [[microgram|μg]]/cm<sup>2</sup> of skin) are available in the [[stratum spinosum]] and [[stratum basale]] of human skin to meet the body's vitamin D requirements. 7-DHC insufficiency has been proposed as an alternate cause for Vitamin D deficiency.<ref name=whackjob>{{cite journal | vauthors = Gokhale S, Bhaduri A | title = Provitamin D<sub>3</sub> modulation through prebiotics supplementation: simulation based assessment | journal = Scientific Reports | volume = 9 | issue = 1 | pages = 19267 | date = December 2019 | pmid = 31848400 | pmc = 6917722 | doi = 10.1038/s41598-019-55699-2 | doi-access = free | bibcode = 2019NatSR...919267G}}</ref>