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Α-Methyltryptamine
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==Side effects== Neurologic side effects of αMT include [[psychomotor agitation|agitation]], [[wikt:restlessness|restlessness]], [[confusion]], and [[lethargy]].<ref name="Barceloux2012" /><ref name="BolandAndolloHime2005" /> Physical manifestations including [[vomiting]], [[mydriasis]] (pupillary dilation), [[bruxism|jaw clenching]], [[tachycardia]], [[salivation]], [[diaphoresis]] (sweating), and [[hypertension|elevations in blood pressure]], [[hyperthermia|temperature]], and [[respiratory rate]].<ref name="Barceloux2012" /><ref name="BolandAndolloHime2005">{{cite journal | vauthors = Boland DM, Andollo W, Hime GW, Hearn WL | title = Fatality due to acute alpha-methyltryptamine intoxication | journal = Journal of Analytical Toxicology | volume = 29 | issue = 5 | pages = 394–397 | date = July–August 2005 | pmid = 16105268 | doi = 10.1093/jat/29.5.394 | quote = α-Methyltryptamine (AMT) is a synthetic drug of the tryptamine family. It is an indole analogue of amphetamine initially investigated as a monoamine oxidase inhibitor. In the 1960s, the Soviet Union marketed AMT as an antidepressant under the name of Indopan. During the same period, Sandoz (as IT-290 and IT-403) and the Upjohn Company (as [U-14,164E]) studied AMT and its commercial use as a stimulant, but found it to be of little medicinal value. Although clinical use of AMT is obsolete today, recreational use has gained popularity because of the intense hallucinogenic properties lasting up to 16 h. To illustrate recreational use of AMT in the 1960s, Alexander Shulgin, in his book TiHKAL, references the author Ken Kesey and his experiences with AMT and other hallucinogenic drugs (1). | doi-access = free }}</ref> Side effects self-reported by recreational users include [[anxiety]], [[muscle tension]], [[trisma|jaw tightness]], [[pupil dilation]], [[tachycardia]], [[headache]]s, [[nausea]], and [[vomiting]], as well as [[Psychedelic drug|psychedelic]] effects including visual hallucinations and an altered state of mind.<ref name="TiHKAL" /><ref name="urlErowid AMT Vault : Effects">{{cite web | url = http://www.erowid.org/chemicals/amt/amt_effects.shtml | work = Erowid Vault | title = AMT Effects }}</ref> αMT is capable of causing life-threatening side effects including [[hyperthermia]], [[hypertension]], and [[tachycardia]].<ref name="BolandAndolloHime2005" /><ref name="Gillman2005">{{cite journal | vauthors = Gillman PK | title = Monoamine oxidase inhibitors, opioid analgesics and serotonin toxicity | journal = British Journal of Anaesthesia | volume = 95 | issue = 4 | pages = 434–441 | date = October 2005 | pmid = 16051647 | doi = 10.1093/bja/aei210 | doi-access = free }} "drugs such as MDMA, ecstasy (3,4-methylenedioxymethamphetamine), if combined with MAOIs (including moclobemide) do also cause fatalities because they act as serotonin releasers"</ref> Fatalities have been reported in association with high doses or concomitant use of other drugs.<ref>{{cite news|title=Call for ban on drug after reveller's death |url=http://www.thisissomerset.co.uk/Torch-carriers-miles-home/story-15588409-detail/story.html#axzz2glqAXLdX | archive-url = https://web.archive.org/web/20131016101947/http://www.thisissomerset.co.uk/Torch-carriers-miles-home/story-15588409-detail/story.html#axzz2glqAXLdX | archive-date = 16 October 2013 |access-date= 1 October 2013 |newspaper=Western Gazette |date=22 March 2012 |url-status=dead }}</ref> Fatalities verified with toxicology and autopsy include those of a 22-year-old man in [[Miami-Dade county]] and a British teenager, both of whom died after consuming 1{{nbsp}}g of αMT.<ref>{{cite news | title = Southampton 'legal high' death deemed 'accidental' | date = 12 November 2013 | url = https://www.bbc.co.uk/news/uk-england-hampshire-24915409 | work = BBC News | access-date = 19 November 2013 }}</ref><ref name="BolandAndolloHime2005" />
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