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=== Type 2 diabetes === People with psoriasis are at increased risk of developing [[type 2 diabetes]] (~1.5 odds ratio).<ref name=":4" /> A [[genome]]-wide genetic study found that psoriasis and type 2 diabetes share four loci, namely, ACTR2, ERLIN1, TRMT112, and BECN1, which are connected via inflammatory NF-ΞΊB pathway.<ref name=":4">{{cite journal | vauthors = Patrick MT, Stuart PE, Zhang H, Zhao Q, Yin X, He K, Zhou XJ, Mehta NN, Voorhees JJ, Boehnke M, Gudjonsson JE, Nair RP, Handelman SK, Elder JT, Liu DJ, Tsoi LC | title = Causal Relationship and Shared Genetic Loci between Psoriasis and Type 2 Diabetes through Trans-Disease Meta-Analysis | journal = The Journal of Investigative Dermatology | volume = 141 | issue = 6 | pages = 1493β1502 | date = June 2021 | pmid = 33385400 | pmc = 8154633 | doi = 10.1016/j.jid.2020.11.025 }}</ref>
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