Editing Progesterone (section)

==Medical use==
{{Main|Progesterone (medication)|Pharmacodynamics of progesterone|Pharmacokinetics of progesterone}}

Progesterone is used as a [[medication]]. It is used in combination with [[estrogen (medication)|estrogen]]s mainly in [[hormone replacement therapy|hormone therapy]] for [[menopause|menopausal]] [[symptom]]s and [[hypogonadism|low sex hormone levels]].<ref name="pmid16112947" /><ref name="pmid28159148">{{cite journal | vauthors = Wesp LM, Deutsch MB | title = Hormonal and Surgical Treatment Options for Transgender Women and Transfeminine Spectrum Persons | journal = The Psychiatric Clinics of North America | volume = 40 | issue = 1 | pages = 99–111 | date = March 2017 | pmid = 28159148 | doi = 10.1016/j.psc.2016.10.006 }}</ref> It may also be used alone to treat menopausal symptoms. Studies have shown that transdermal progesterone (skin patch) and oral micronized progesterone are effective treatments for certain symptoms of menopause such as hot flashes and night sweats, which are otherwise referred to as vasomotor symptoms or VMS.<ref name="pmid33109992">{{cite journal | vauthors = Dolitsky SN, Cordeiro Mitchell CN, Stadler SS, Segars JH | title = Efficacy of progestin-only treatment for the management of menopausal symptoms: a systematic review | journal = Menopause | volume = 28 | issue = 2 | pages = 217–224 | date = November 2020 | pmid = 33109992 | doi = 10.1097/GME.0000000000001676 | s2cid = 225100434 }}</ref>

It is also used to support [[pregnancy]] and [[fertility]] and to treat [[gynecological disorder]]s.<ref name="pmid25113944">{{cite journal | vauthors = Ruan X, Mueck AO | title = Systemic progesterone therapy--oral, vaginal, injections and even transdermal? | journal = Maturitas | volume = 79 | issue = 3 | pages = 248–255 | date = November 2014 | pmid = 25113944 | doi = 10.1016/j.maturitas.2014.07.009 }}</ref><ref name="pmid26443945">{{cite journal | vauthors = Filicori M | title = Clinical roles and applications of progesterone in reproductive medicine: an overview | journal = Acta Obstetricia et Gynecologica Scandinavica | volume = 94 | issue = Suppl 161 | pages = 3–7 | date = November 2015 | pmid = 26443945 | doi = 10.1111/aogs.12791 | doi-access = free }}</ref><ref name="pmid26345161">{{cite journal | vauthors = Ciampaglia W, Cognigni GE | title = Clinical use of progesterone in infertility and assisted reproduction | journal = Acta Obstetricia et Gynecologica Scandinavica | volume = 94 | issue = Suppl 161 | pages = 17–27 | date = November 2015 | pmid = 26345161 | doi = 10.1111/aogs.12770 | s2cid = 40753277 | doi-access = free }}</ref><ref name="pmid28989916">{{cite journal | vauthors = Choi SJ | title = Use of progesterone supplement therapy for prevention of preterm birth: review of literatures | journal = Obstetrics & Gynecology Science | volume = 60 | issue = 5 | pages = 405–420 | date = September 2017 | pmid = 28989916 | pmc = 5621069 | doi = 10.5468/ogs.2017.60.5.405 }}</ref> Progesterone has been shown to  prevent miscarriage in those with 1) vaginal bleeding early in their current pregnancy and 2) a previous history of miscarriage.<ref name="pmid32609084">{{cite journal | vauthors = Coomarasamy A, Harb HM, Devall AJ, Cheed V, Roberts TE, Goranitis I, Ogwulu CB, Williams HM, Gallos ID, Eapen A, Daniels JP, Ahmed A, Bender-Atik R, Bhatia K, Bottomley C, Brewin J, Choudhary M, Crosfill F, Deb S, Duncan WC, Ewer A, Hinshaw K, Holland T, Izzat F, Johns J, Lumsden MA, Manda P, Norman JE, Nunes N, Overton CE, Kriedt K, Quenby S, Rao S, Ross J, Shahid A, Underwood M, Vaithilingham N, Watkins L, Wykes C, Horne AW, Jurkovic D, Middleton LJ | display-authors = 6 | title = Progesterone to prevent miscarriage in those with early pregnancy bleeding: the PRISM RCT | language = EN | journal = Health Technology Assessment | volume = 24 | issue = 33 | pages = 1–70 | date = June 2020 | pmid = 32609084 | pmc = 7355406 | doi = 10.3310/hta24330 | doi-access = free }}</ref> Progesterone can be taken [[oral administration|by mouth]], [[intravaginal administration|through the vagina]], and by [[injection (medicine)|injection]] into [[muscle]] or [[fat]], among other [[route of administration|route]]s.<ref name="pmid16112947" />