Editing Tocopherol (section)

==History==
During feeding experiments with rats [[Herbert McLean Evans]] concluded in 1922 that besides vitamins B and C, an unknown vitamin existed.<ref>{{cite journal | vauthors = Evans HM, Bishop KS | title = On the Existence of a Hitherto Unrecognized Dietary Factor Essential for Reproduction  | journal = Science | volume = 56 | issue = 1458 | pages = 650–1 | date = December 1922 | pmid = 17838496 | doi = 10.1126/science.56.1458.650 | bibcode = 1922Sci....56..650E | url = https://zenodo.org/record/1448277 }}</ref> Although every other nutrition was present, the rats were not fertile. This condition could be changed by additional feeding with wheat germ. It took several years until 1936 when the substance was isolated from wheat germ and the formula C<sub>29</sub>H<sub>50</sub>O<sub>2</sub> was determined. Evans also found that the compound reacted like an [[Alcohol (chemistry)|alcohol]] and concluded that one of the oxygen atoms was part of an OH (hydroxyl) group. As noted in the introduction, the vitamin was given its name by Evans from Greek words meaning "to bear young" with the addition of the -ol as an alcohol.<ref>{{cite journal| author1 = Evans H. M.| author2 = Emerson O. H.| author3 = Emerson G. A.| title = The isolation from wheat germ oil of an alcohol, a-tocopherol, having the properties of vitamin E| journal = Journal of Biological Chemistry| date = 1 February 1936| volume = 113| issue = 1| pages = 319–332| doi = 10.1016/S0021-9258(18)74918-1| url = http://www.jbc.org/cgi/reprint/113/1/319| url-status = live| archive-url = https://web.archive.org/web/20070929091434/http://www.jbc.org/cgi/reprint/113/1/319| archive-date = 29 September 2007| doi-access = free}}</ref>
The structure was determined shortly thereafter in 1938.<ref>{{cite journal |last1=Fernholz |first1=E. |journal=Journal of the American Chemical Society |volume=60 |pages=700–705 |year=1938 |doi=10.1021/ja01270a057 |issue=3 |title=On the Constitution of α-Tocopherol|bibcode=1938JAChS..60..700F }}</ref>