Editing Nicotine (section)

===Preparation===
The first laboratory preparation of nicotine (as its [[racemate]]) was described in 1904.<ref name=Pictet>{{cite journal |title=Synthese des Nicotins |trans-title=Synthesis of nicotine |language=de |year=1904 | vauthors=Pictet A, Rotschy A |journal=Berichte der Deutschen Chemischen Gesellschaft |volume=37 |issue=2 |pages=1225–1235 |doi=10.1002/cber.19040370206 |url=https://zenodo.org/record/1426104 }}</ref>
[[File:Nicotine synthesis 1904.svg|650px|class=skin-invert-image]]
The starting material was an N-substituted [[pyrrole]] derivative, which was heated to convert it by a [[Sigmatropic reaction|[1,5] sigmatropic shift]] to the [[isomer]] with a carbon bond between the pyrrole and pyridine rings, followed by [[methylation]] and selective reduction of the pyrrole ring using tin and hydrochloric acid.<ref name=Pictet/><ref>{{cite journal |doi=10.1002/hlca.200490241 |title=A New Approach to Nicotine: Symmetry Consideration for Synthesis Design |year=2004 | vauthors = Ho TL, Kuzakov EV |journal=Helvetica Chimica Acta |volume=87 |issue=10 |pages=2712–2716 }}</ref> Many other syntheses of nicotine, in both racemic and chiral forms have since been published.<ref>{{cite journal |doi=10.1002/slct.202104425 |title=Research Progress in the Pharmacological Effects and Synthesis of Nicotine |year=2022 | vauthors = Ye X, Zhang Y, Song X, Liu Q |journal=ChemistrySelect |volume=7 |issue=12 |s2cid=247687372 }}</ref>