Editing Life extension (section)

====Complications====
Complications of antioxidant supplementation (especially continuous high dosages far above the [[Recommended Daily Allowance|RDA]]) include that [[reactive oxygen species]] (ROS), which are mitigated by antioxidants, "have been found to be physiologically vital for signal transduction, gene regulation, and redox regulation, among others, implying that their complete elimination would be harmful". In particular, one way of multiple they can be detrimental is by inhibiting adaptation to exercise such as [[muscle hypertrophy]] (e.g. during [[bodybuilding|dedicated periods]] of caloric surplus).<ref>{{cite journal | vauthors = Damiano S, Muscariello E, La Rosa G, Di Maro M, Mondola P, Santillo M | title = Dual Role of Reactive Oxygen Species in Muscle Function: Can Antioxidant Dietary Supplements Counteract Age-Related Sarcopenia? | journal = International Journal of Molecular Sciences | volume = 20 | issue = 15 | pages = E3815 | date = August 2019 | pmid = 31387214 | pmc = 6696113 | doi = 10.3390/ijms20153815 | doi-access = free }}</ref><ref>{{cite journal | vauthors = Badran A, Nasser SA, Mesmar J, El-Yazbi AF, Bitto A, Fardoun MM, Baydoun E, Eid AH | display-authors = 6 | title = Reactive Oxygen Species: Modulators of Phenotypic Switch of Vascular Smooth Muscle Cells | journal = International Journal of Molecular Sciences | volume = 21 | issue = 22 | pages = 8764 | date = November 2020 | pmid = 33233489 | doi = 10.3390/ijms21228764 | pmc = 7699590 | doi-access = free }}</ref><ref>{{cite journal | vauthors = Sohal RS, Orr WC | title = The redox stress hypothesis of aging | journal = Free Radical Biology & Medicine | volume = 52 | issue = 3 | pages = 539–555 | date = February 2012 | pmid = 22080087 | pmc = 3267846 | doi = 10.1016/j.freeradbiomed.2011.10.445 }}</ref> There is also research into stimulating/activating/fueling endogenous antioxidant generation, in particular e.g. of neutraceutical glycine and pharmaceutical NAC.<ref>{{cite journal | vauthors = McCarty MF, O'Keefe JH, DiNicolantonio JJ | title = Dietary Glycine Is Rate-Limiting for Glutathione Synthesis and May Have Broad Potential for Health Protection | journal = The Ochsner Journal | volume = 18 | issue = 1 | pages = 81–87 | date = 2018 | pmid = 29559876 | pmc = 5855430 }}</ref> Antioxidants can change the oxidation status of different e.g. tissues, targets or sites each with potentially different implications, especially for different concentrations.<ref>{{cite journal | vauthors = Griffiths HR | title = Antioxidants and protein oxidation | journal = Free Radical Research | volume = 33 | issue = Supplement | pages = S47–S58 | date = November 2000 | pmid = 11191275 | url = https://publications.aston.ac.uk/id/eprint/39762/ }}</ref><ref>{{cite journal | vauthors = Cobley JN | title = Mechanisms of Mitochondrial ROS Production in Assisted Reproduction: The Known, the Unknown, and the Intriguing | journal = Antioxidants | volume = 9 | issue = 10 | pages = 933 | date = September 2020 | pmid = 33003362 | pmc = 7599503 | doi = 10.3390/antiox9100933 | doi-access = free }}</ref><ref>{{cite journal | title = Nutritional Antioxidants: It Is Time to Categorise | journal = Antioxidants in Sport Nutrition | date = 2015 | pmid = 26065087 | url = https://pubmed.ncbi.nlm.nih.gov/26065087/ | publisher = CRC Press/Taylor & Francis | isbn = 9781466567573 | last1 = Bast | first1 = A. | author2 = Haenen GRMM | last3 = Lamprecht | first3 = M. }}</ref><ref>{{cite journal |last1=Lobo |first1=V |last2=Patil |first2=A |last3=Phatak |first3=A |last4=Chandra |first4=N |date=2010 |title=Free radicals, antioxidants and functional foods: Impact on human health |journal=Pharmacognosy Reviews |volume=4 |issue=8 |pages=118–126 |doi=10.4103/0973-7847.70902 |pmid=22228951 |pmc=3249911 |doi-access=free }}</ref> A review suggests [[mitochondria]] have a [[hormesis|hormetic]] response to ROS, whereby low oxidative damage can be beneficial.<ref>{{cite journal | vauthors = Hood WR, Zhang Y, Mowry AV, Hyatt HW, Kavazis AN | title = Life History Trade-offs within the Context of Mitochondrial Hormesis | journal = Integrative and Comparative Biology | volume = 58 | issue = 3 | pages = 567–577 | date = September 2018 | pmid = 30011013 | pmc = 6145418 | doi = 10.1093/icb/icy073 }}</ref>