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====Allergic reactions==== Some people develop a [[hypersensitivity]] to products and foods containing iodine. Applications of tincture of iodine or Betadine can cause rashes, sometimes severe.<ref name="dermnet">DermNet New Zealand Trust, [http://www.dermnetnz.org/treatments/iodine.html Iodine] {{Webarchive|url=https://web.archive.org/web/20160707101355/http://www.dermnetnz.org/treatments/iodine.html |date=7 July 2016 }}</ref> [[wikt:parenteral|Parenteral]] use of iodine-based contrast agents (see above) can cause reactions ranging from a mild rash to fatal [[anaphylaxis]]. Such reactions have led to the misconception (widely held, even among physicians) that some people are allergic to iodine itself; even allergies to iodine-rich foods have been so construed.<ref>{{cite journal | vauthors = Boehm I | title = Seafood allergy and radiocontrast media: are physicians propagating a myth? | journal = The American Journal of Medicine | volume = 121 | issue = 8 | pages = e19 | date = August 2008 | pmid = 18691465 | doi = 10.1016/j.amjmed.2008.03.035 | doi-access = free }}</ref> In fact, there has never been a confirmed report of a true iodine allergy, as an allergy to iodine or iodine salts is biologically impossible. Hypersensitivity reactions to products and foods containing iodine are apparently related to their other molecular components;<ref name="ucsf">UCSF Department of Radiology & Biomedical Imaging, [http://www.radiology.ucsf.edu/patient-care/patient-safety/contrast/iodine-allergy Iodine Allergy and Contrast Administration] {{Webarchive|url=https://web.archive.org/web/20210409132913/http://www.radiology.ucsf.edu/patient-care/patient-safety/contrast/iodine-allergy |date=9 April 2021 }}</ref> thus, a person who has demonstrated an allergy to one food or product containing iodine may not have an allergic reaction to another. Patients with various food allergies (fishes, shellfishes, eggs, milk, seaweeds, kelp, meats, vegetables, kombu, wakame) do not have an increased risk for a contrast medium hypersensitivity.<ref name="pmid31153557">{{cite journal | vauthors = Lombardo P, Nairz K, Boehm I | title = Patients' safety and the "iodine allergy" - How should we manage patients with iodine allergy before they receive an iodinated contrast medium? | journal = European Journal of Radiology | volume = 116 | issue = 7 | pages = 150β151 | date = July 2019 | pmid = 31153557 | doi = 10.1016/j.ejrad.2019.05.002 | s2cid = 164898934 }}</ref><ref name="ucsf" /> The patient's allergy history is relevant.<ref>{{cite journal | vauthors = Katelaris C |date=2009 |title='Iodine Allergy' label is misleading |journal=Australian Prescriber |volume=32 |pages=125β128 |issue=5 |doi=10.18773/austprescr.2009.061 |doi-access=free }}</ref> {{clear|right}}
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