Editing Inflammation (section)

====Role in cancer====

In 1863, [[Rudolf Virchow]] hypothesized that the origin of cancer was at sites of chronic inflammation.<ref name="Coussens">{{Cite journal |vauthors=Coussens LM, Werb Z |year=2002 |title=Inflammation and cancer |journal=Nature |volume=420 |issue=6917 |pages=860–7 |bibcode=2002Natur.420..860C |doi=10.1038/nature01322 |pmc=2803035 |pmid=12490959}}</ref><ref name="Chiba">{{Cite journal |vauthors=Chiba T, Marusawa H, Ushijima T |date=September 2012 |title=Inflammation-associated cancer development in digestive organs: mechanisms and roles for genetic and epigenetic modulation |url=http://repository.kulib.kyoto-u.ac.jp/dspace/bitstream/2433/160134/1/j.gastro.2012.07.009.pdf |url-status=live |journal=Gastroenterology |volume=143 |issue=3 |pages=550–563 |doi=10.1053/j.gastro.2012.07.009 |pmid=22796521 |s2cid=206226588 |archive-url=https://web.archive.org/web/20220829232437/https://repository.kulib.kyoto-u.ac.jp/dspace/bitstream/2433/160134/1/j.gastro.2012.07.009.pdf |archive-date=29 August 2022 |access-date=9 June 2018 |hdl-access=free |hdl=2433/160134}}</ref> As of 2012, chronic inflammation was estimated to contribute to approximately 15% to 25% of human cancers.<ref name="Chiba" /><ref name="pmid18650914">{{Cite journal |vauthors=Mantovani A, Allavena P, Sica A, Balkwill F |date=July 2008 |title=Cancer-related inflammation |url=https://air.unimi.it/bitstream/2434/145688/2/Cancer-related%20inflammation_Nature.pdf |url-status=live |journal=Nature |volume=454 |issue=7203 |pages=436–44 |bibcode=2008Natur.454..436M |doi=10.1038/nature07205 |pmid=18650914 |s2cid=4429118 |archive-url=https://web.archive.org/web/20221030195610/https://air.unimi.it/bitstream/2434/145688/2/Cancer-related%20inflammation_Nature.pdf |archive-date=30 October 2022 |access-date=9 June 2018 |hdl-access=free |hdl=2434/145688}}</ref>