Editing Chlorine (section)

==Biological role==
The [[chloride]] anion is an [[Mineral (nutrient)|essential nutrient]] for metabolism. Chlorine is needed for the production of [[hydrochloric acid]] in the stomach and in cellular pump functions.<ref>{{cite web|url=http://www.med.umich.edu/1libr/aha/aha_schlorid_crs.htm |access-date=30 April 2010 |url-status=dead |archive-url=https://web.archive.org/web/20090331211149/http://med.umich.edu/1libr/aha/aha_schlorid_crs.htm |archive-date=31 March 2009 |title=Blood (Serum) Chloride Level Test}}</ref> The main dietary source is table salt, or sodium chloride. Overly low or high concentrations of chloride in the blood are examples of [[electrolyte disturbance]]s. [[Hypochloremia]] (having too little chloride) rarely occurs in the absence of other abnormalities. It is sometimes associated with [[hypoventilation]].<ref name="pmid3764530">{{cite journal |last1=Lavie|first1=CJ| last2=Crocker|first2=EF|last3=Key|first3=KJ |last4=Ferguson|first4=TG |title=Marked hypochloremic metabolic alkalosis with severe compensatory hypoventilation |journal=South. Med. J. |volume=79 |issue=10 |pages=1296–99 |date=October 1986 |pmid=3764530 |doi= 10.1097/00007611-198610000-00025}}</ref> It can be associated with chronic [[respiratory acidosis]].<ref name="pmid13611033">{{cite journal |last1=Levitin|first1=H |last2=Branscome|first2=W |last3=Epstein|first3=FH |title=The pathogenesis of hypochloremia in respiratory acidosis |journal=J. Clin. Invest. |volume=37 |issue=12 |pages=1667–75 |date=December 1958 |pmid=13611033 |pmc=1062852 |doi=10.1172/JCI103758}}</ref> [[Hyperchloremia]] (having too much chloride) usually does not produce symptoms. When symptoms do occur, they tend to resemble those of [[hypernatremia]] (having too much [[sodium]]). Reduction in blood chloride leads to cerebral dehydration; symptoms are most often caused by rapid rehydration which results in [[cerebral edema]]. Hyperchloremia can affect oxygen transport.<ref name="pmid9760315">{{cite journal |last1=Cambier|first1=C |last2=Detry|first2=B |last3=Beerens|first3=D|last4=Florquin|display-authors=3 |title=Effects of hyperchloremia on blood oxygen binding in healthy calves |journal=J. Appl. Physiol. |volume=85 |issue=4 |pages=1267–72 |date=October 1998 |pmid=9760315 |doi= 10.1152/jappl.1998.85.4.1267}}</ref>