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===Modern-day=== Modern treatment methods include [[insecticide]]s, the use of [[antibiotic]]s, and a [[plague vaccine]]. It is feared that the plague bacterium could develop [[drug resistance]] and again become a major health threat. One case of a drug-resistant form of the bacterium was found in [[Madagascar]] in 1995.<ref>{{Cite web |url=http://www.scidev.net/en/health/antibiotic-resistance/news/drugresistant-plague-a-major-threat-say-scient.html |title=Drug-resistant plague a 'major threat', say scientists |date=23 March 2007 |first=T.V. |last=Padma |website=SciDev.net |url-status=live |archiveurl=https://web.archive.org/web/20120719034621/http://www.scidev.net/en/health/antibiotic-resistance/news/drugresistant-plague-a-major-threat-say-scient.html |archivedate=19 July 2012}}</ref> Another outbreak in Madagascar was reported in November 2014.<ref>{{cite web |url=https://www.who.int/csr/don/21-november-2014-plague/en/ |title=Plague β Madagascar |date=21 November 2014 |publisher=World Health Organisation |access-date=26 November 2014 |archive-url=https://web.archive.org/web/20190502001426/https://www.who.int/csr/don/21-november-2014-plague/en/ |archive-date=2 May 2019 |url-status=dead }}</ref> In October 2017, the [[21st-century Madagascar plague outbreaks|deadliest outbreak of the plague]] in modern times hit Madagascar, killing 170 people and infecting thousands.<ref>{{Cite news|url=https://www.wsj.com/articles/madagascar-wrestles-with-worst-outbreak-of-plague-in-half-a-century-1510788541|title=Madagascar Wrestles With Worst Outbreak of Plague in Half a Century |first1=Alexandra |last1=Wexler |first2=Amir |last2=Antoy |date=16 November 2017|work=[[The Wall Street Journal]]|access-date=17 November 2017|language=en-US |archive-url= https://web.archive.org/web/20171117010725/https://www.wsj.com/articles/madagascar-wrestles-with-worst-outbreak-of-plague-in-half-a-century-1510788541|archive-date=17 November 2017|url-status=live}}</ref> An estimate of the [[case fatality rate]] for the modern [[Plague (disease)|plague]], after the introduction of [[antibiotic]]s, is 11%, although it may be higher in underdeveloped regions.<ref>{{cite web|url=https://www.cdc.gov/plague/faq/index.html|author=Centers for Disease Control (CDC)|title=FAQ: Plague|date=24 September 2015|access-date=24 April 2017|archive-url=https://web.archive.org/web/20190330171757/https://www.cdc.gov/plague/faq/index.html|archive-date=30 March 2019|url-status=live}}</ref>
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