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=== Preoperative anemia === An estimated 30% of adults who require non-cardiac surgery have anemia.<ref name="Kaufner von Heymann Henkelmann et al 2020">{{cite journal |last1=Kaufner |first1=Lutz |last2=von Heymann |first2=Christian |last3=Henkelmann |first3=Anne |last4=Pace |first4=Nathan L |last5=Weibel |first5=Stephanie |last6=Kranke |first6=Peter |last7=Meerpohl |first7=Joerg J |last8=Gill |first8=Ravi |title=Erythropoietin plus iron versus control treatment including placebo or iron for preoperative anaemic adults undergoing non-cardiac surgery |journal=Cochrane Database of Systematic Reviews |date=13 August 2020 |volume=2020 |issue=8 |pages=CD012451 |doi=10.1002/14651858.CD012451.pub2 |pmid=32790892 |pmc=8095002 }}</ref> In order to determine an appropriate preoperative treatment, it is suggested that the cause of anemia be first determined.<ref>{{cite journal |last1=KotzΓ© |first1=Alwyn |last2=Harris |first2=Andrea |last3=Baker |first3=Charles |last4=Iqbal |first4=Tariq |last5=Lavies |first5=Nick |last6=Richards |first6=Toby |last7=Ryan |first7=Kate |last8=Taylor |first8=Craig |last9=Thomas |first9=Dafydd |title=British Committee for Standards in Haematology Guidelines on the Identification and Management of Pre-Operative Anaemia |journal=British Journal of Haematology |date=November 2015 |volume=171 |issue=3 |pages=322β331 |doi=10.1111/bjh.13623 |pmid=26343392 |s2cid=37709527 |doi-access=free }}</ref> There is moderate level medical evidence that supports a combination of iron supplementation and erythropoietin treatment to help reduce the requirement for red blood cell transfusions after surgery in those who have preoperative anemia.<ref name="Kaufner von Heymann Henkelmann et al 2020"/>
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