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===Alternative medicine=== An experimental treatment, [[enzyme potentiated desensitization]] (EPD), has been tried for decades but is not generally accepted as effective.<ref name="pmid15042943"/> EPD uses dilutions of allergen and an enzyme, [[beta-glucuronidase]], to which [[T-lymphocytes, regulatory|T-regulatory lymphocytes]] are supposed to respond by favoring desensitization, or down-regulation, rather than sensitization. EPD has also been tried for the treatment of [[autoimmune diseases]], but evidence does not show effectiveness.<ref name="pmid15042943" /> A review found no effectiveness of [[homeopathic treatment]]s and no difference compared with [[placebo]]. The authors concluded that based on rigorous clinical trials of all types of homeopathy for childhood and adolescence ailments, there is no convincing evidence that supports the use of homeopathic treatments.<ref name="pmid17285788"/> According to the [[National Center for Complementary and Integrative Health]], U.S., the evidence is relatively strong that [[saline nasal irrigation]] and [[butterbur]] are effective, when compared to other [[alternative medicine]] treatments, for which the scientific evidence is weak, negative, or nonexistent, such as honey, acupuncture, omega 3's, probiotics, astragalus, capsaicin, grape seed extract, Pycnogenol, quercetin, spirulina, stinging nettle, tinospora, or guduchi. <ref>{{cite web |url=http://www.webmd.com/allergies/ss/slideshow-natural-relief |title=12 Natural Ways to Defeat Allergies |access-date=3 July 2016 |url-status=live |archive-url=https://web.archive.org/web/20160702011133/http://www.webmd.com/allergies/ss/slideshow-natural-relief |archive-date=2 July 2016 }}</ref><ref>{{cite web |url=https://nccih.nih.gov/health/providers/digest/allergies-science |title=Seasonal Allergies and Complementary Health Approaches: What the Science Says |access-date=3 July 2016 |url-status=live |archive-url=https://web.archive.org/web/20160705152320/https://nccih.nih.gov/health/providers/digest/allergies-science |archive-date=5 July 2016 |date=11 April 2013 }}</ref>
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