Editing Zebrafish (section)

===Inbreeding depression===
When close relatives mate, progeny may exhibit the detrimental effects of [[inbreeding depression]]. Inbreeding depression is predominantly caused by the [[Zygosity#homozygous|homozygous]] expression of recessive deleterious alleles.<ref name="pmid19834483">{{cite journal |vauthors=Charlesworth D, Willis JH |title=The genetics of inbreeding depression |journal=[[Nature Reviews Genetics]] |volume=10 |issue=11 |pages=783–796 |date=November 2009 |pmid=19834483 |doi=10.1038/nrg2664 |s2cid=771357}}</ref> For zebrafish, inbreeding depression might be expected to be more severe in stressful environments, including those caused by [[Human impact on the environment|anthropogenic pollution]]. Exposure of zebrafish to environmental stress induced by the chemical clotrimazole, an imidazole fungicide used in agriculture and in veterinary and human medicine, amplified the effects of inbreeding on key reproductive traits.<ref name="pmid23798977">{{cite journal |vauthors=Bickley LK, Brown AR, Hosken DJ, Hamilton PB, Le Page G, Paull GC, Owen SF, Tyler CR |display-authors=6 |title=Interactive effects of inbreeding and endocrine disruption on reproduction in a model laboratory fish |journal=Evolutionary Applications |volume=6 |issue=2 |pages=279–289 |date=February 2013 |pmid=23798977 |pmc=3689353 |doi=10.1111/j.1752-4571.2012.00288.x |bibcode=2013EvApp...6..279B}}</ref> Embryo viability was significantly reduced in inbred exposed fish and there was a tendency for inbred males to sire fewer offspring.