Editing Life extension (section)

====Vitamins and antioxidants====
{{See also|Inflammaging|DNA damage theory of aging}}
The [[free-radical theory of aging]] suggests that [[antioxidant]] supplements might extend human life. Reviews, however, have found that use of vitamin A (as β-carotene) and vitamin E supplements possibly can increase mortality.<ref>{{cite journal | vauthors = Bjelakovic G, Nikolova D, Gluud LL, Simonetti RG, Gluud C | title = Mortality in randomized trials of antioxidant supplements for primary and secondary prevention: systematic review and meta-analysis | journal = JAMA | volume = 297 | issue = 8 | pages = 842–857 | date = February 2007 | pmid = 17327526 | doi = 10.1001/jama.297.8.842 }}</ref><ref>{{cite journal | vauthors = Bjelakovic G, Nikolova D, Gluud LL, Simonetti RG, Gluud C | title = Antioxidant supplements for prevention of mortality in healthy participants and patients with various diseases | journal = The Cochrane Database of Systematic Reviews | volume = 2012 | issue = 3 | pages = CD007176 | date = March 2012 | pmid = 22419320 | pmc = 8407395 | doi = 10.1002/14651858.CD007176.pub2 | hdl-access = free | hdl = 10138/136201 }}</ref> Other reviews have found no relationship between vitamin E and other vitamins with mortality.<ref>{{cite journal | vauthors = Jiang S, Pan Z, Li H, Li F, Song Y, Qiu Y | title = Meta-analysis: low-dose intake of vitamin E combined with other vitamins or minerals may decrease all-cause mortality | journal = Journal of Nutritional Science and Vitaminology | volume = 60 | issue = 3 | pages = 194–205 | year = 2014 | pmid = 25078376 | doi = 10.3177/jnsv.60.194 | quote = Neither vitamin E intake alone nor combined with other agents is associated with a reduction in all-cause mortality. | doi-access = free }}</ref> [[Vitamin D]] supplementation of various dosages is investigated in trials<ref>{{cite journal | vauthors = Garay RP | title = Investigational drugs and nutrients for human longevity. Recent clinical trials registered in ClinicalTrials.gov and clinicaltrialsregister.eu | journal = Expert Opinion on Investigational Drugs | volume = 30 | issue = 7 | pages = 749–758 | date = July 2021 | pmid = 34081543 | doi = 10.1080/13543784.2021.1939306 | s2cid = 235334397 }}</ref> and there also is research into GlyNAC {{see above|[[#GlyNAC|above]]}}.<ref name="Sekhar-2021"/>