Editing Hippocampus (section)

=== Microcephaly ===

Hippocampus atrophy has been characterized in those with [[microcephaly]].<ref>{{cite journal | vauthors = Bilgüvar K, Oztürk AK, Louvi A, Kwan KY, Choi M, Tatli B, Yalnizoğlu D, Tüysüz B, Cağlayan AO, Gökben S, Kaymakçalan H, Barak T, Bakircioğlu M, Yasuno K, Ho W, Sanders S, Zhu Y, Yilmaz S, Dinçer A, Johnson MH, Bronen RA, Koçer N, Per H, Mane S, Pamir MN, Yalçinkaya C, Kumandaş S, Topçu M, Ozmen M, Sestan N, Lifton RP, State MW, Günel M | title = Whole-exome sequencing identifies recessive WDR62 mutations in severe brain malformations | journal = Nature | volume = 467 | issue = 7312 | pages = 207–210 | date = September 2010 | pmid = 20729831 | pmc = 3129007 | doi = 10.1038/nature09327 | bibcode = 2010Natur.467..207B }}</ref> Mouse models with [[WDR62|Wdr62]] mutations which recapitulate human [[point mutation]]s show a deficiency in hippocampal development, and [[neurogenesis]].<ref name="Shohayeb_2020">{{cite journal | vauthors = Shohayeb B, Ho UY, Hassan H, Piper M, Ng DC | title = The Spindle-Associated Microcephaly Protein, WDR62, Is Required for Neurogenesis and Development of the Hippocampus | journal = Frontiers in Cell and Developmental Biology | volume = 8 | issue = | pages = 549353 | date = 2020 | pmid = 33042990 | pmc = 7517699 | doi = 10.3389/fcell.2020.549353 | doi-access = free }}</ref>