Editing Bipolar disorder (section)

====Antidepressants====
[[Antidepressants|Antidepressant]] monotherapy is not recommended in the treatment of bipolar disorder and does not provide any benefit over mood stabilizers.<ref name=Lancet2016/><ref name="PostGrad10">{{cite journal |vauthors=El-Mallakh RS, Elmaadawi AZ, Loganathan M, Lohano K, Gao Y | title = Bipolar disorder: an update | journal = Postgraduate Medicine | volume = 122 | issue = 4 | pages = 24–31 | date = July 2010 | pmid = 20675968 | doi = 10.3810/pgm.2010.07.2172 | s2cid = 43749362 }}</ref> Atypical [[antipsychotic medication]]s (e.g., [[aripiprazole]]) are preferred over antidepressants to augment the effects of mood stabilizers due to the lack of efficacy of antidepressants in bipolar disorder. Treatment of bipolar disorder using antidepressants may carry a risk of affective switches where a person switches from depression to manic or hypomanic phases or mixed states.<ref name="Carvalho" /> There may also be a risk of accelerating cycling between phases when antidepressants are used in bipolar disorder. The risk of affective switches is higher in bipolar I depression; antidepressants are generally avoided in bipolar I disorder or only used with mood stabilizers when they are deemed necessary.<ref>Chris Aiken: [https://www.psychiatrictimes.com/view/antidepressants-bipolar-ii-disorder ''Antidepressants in Bipolar II Disorder''], May 14, 2019. In: psychiatrictimes.com</ref><ref name="Carvalho" />{{rp|63}}

Whether modern antidepressants cause mania or cycle acceleration in bipolar disorder is highly controversial, as is whether antidepressants provide any benefit over mood stabilizers alone.<ref name="Carvalho" />{{rp|63}}<ref>{{cite journal | vauthors = Gitlin MJ | title = Antidepressants in bipolar depression: an enduring controversy | journal = International Journal of Bipolar Disorders | volume = 6 | issue = 1 | pages = 25 | date = December 2018 | pmid = 30506151 | pmc = 6269438 | doi = 10.1186/s40345-018-0133-9 | doi-access = free }}</ref>
{{See also|SSRI#Bipolar switch}}