Editing Beta blocker (section)

== Comparative information ==

=== Pharmacological differences ===
* Agents with intrinsic sympathomimetic action (ISA)
** Acebutolol,<ref name="BB in HTN Meta-analyses">{{cite journal | vauthors = Larochelle P, Tobe SW, Lacourcière Y | title = β-Blockers in hypertension: studies and meta-analyses over the years | journal = The Canadian Journal of Cardiology | volume = 30 | issue = 5 Suppl | pages = S16–S22 | date = May 2014 | pmid = 24750978 | doi = 10.1016/j.cjca.2014.02.012 | doi-access = free }}</ref> pindolol,<ref name="BB in HTN Meta-analyses" /> labetalol,<ref name="BB in HTN Meta-analyses" /> mepindolol,<ref>{{cite book| veditors = Ganten D, Mulrow PJ |title=Pharmacology of Antihypertensive Therapeutics |date=1990 |publisher=Springer Berlin Heidelberg|location=Berlin, Heidelberg|isbn=9783642742095|page=523}}</ref> oxprenolol,<ref name="oxprenolol" /> celiprolol,<ref name="Celiprolol" /> penbutolol<ref name="PharmLetter BB Table" />
* Agents organized by lipid solubility (lipophilicity)<ref>{{cite journal | vauthors = Zipursky JS, Macdonald EM, Luo J, Gomes T, Mamdani MM, Paterson JM, Juurlink DN | title = Lipophilic β-Blockers and Suicide in the Elderly | journal = Journal of Clinical Psychopharmacology | volume = 37 | issue = 3 | pages = 381–384 | date = June 2017 | pmid = 28338548 | doi = 10.1097/JCP.0000000000000695 | s2cid = 23355130 }}</ref>
** High lipophilicity: propranolol, labetalol
** Intermediate lipophilicity: metoprolol, bisoprolol, carvedilol, acebutolol, timolol, pindolol
** Low lipophilicity (also known as hydrophilic beta blockers): atenolol, nadolol, and sotalol
* Agents with [[membrane stabilizing effect]]<ref name="Aronson">{{cite journal | vauthors = Aronson JK | title = Changing beta-blockers in heart failure: when is a class not a class? | journal = The British Journal of General Practice | volume = 58 | issue = 551 | pages = 387–389 | date = June 2008 | pmid = 18505613 | pmc = 2418988 | doi = 10.3399/bjgp08X299317 }}</ref>
** Carvedilol, propranolol > oxprenolol > labetalol, metoprolol, timolol

=== Indication differences ===
* Agents specifically labeled for cardiac arrhythmia
** [[Esmolol]],<ref name="Esmolol package insert">{{Cite web |title=DailyMed - BREVIBLOC- esmolol hydrochloride injection |url=https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=595cc3d5-1306-4828-aefa-5595219ffd62 |access-date=2022-11-09 | work = DailyMed | publisher = U.S. National Library of Medicine }}</ref> [[sotalol]],<ref>{{Cite web |title=DailyMed - BETAPACE- sotalol hydrochloride tablet BETAPACE AF- sotalol hydrochloride tablet |url=https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=afce2787-8899-4098-87c8-f1e8dd19e6dd |access-date=2022-11-09 | work = DailyMed | publisher = U.S. National Library of Medicine }}</ref> [[landiolol]] (Japan)<ref>{{cite web|title=Announcement of Approval of Additional Indications for Onoact 50 for Injection, Short-Acting Selective ß1 Blocker|url=http://www.evaluategroup.com/Universal/View.aspx?type=Story&id=103244|website=www.evaluategroup.com|publisher=Evaluate Ltd.|access-date=18 October 2017}}</ref>
* Agents specifically labeled for congestive heart failure<ref name="PharmLetter BB Table" />
** [[Bisoprolol]], [[carvedilol]], [[metoprolol|sustained-release metoprolol]]
* Agents specifically labeled for glaucoma
** [[Betaxolol]],<ref name="Aronson" /> [[carteolol]],<ref name="Aronson" /> [[levobunolol]],<ref name="Aronson" /> [[timolol]],<ref name="Aronson" /> [[metipranolol]]<ref>{{cite web|title=Metiprapanol – metipranolol solution/ drops|url=https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=699ce415-0798-4244-b5ec-bcdb383b50b3| work = DailyMed | publisher = U.S. National Library of Medicine – NIH|access-date=18 October 2017|url-status=live|archive-url=https://web.archive.org/web/20171018133648/https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=699ce415-0798-4244-b5ec-bcdb383b50b3|archive-date=October 18, 2017|df=mdy-all}}</ref>
* Agents specifically labeled for myocardial infarction<ref name="PharmLetter BB Table" />
** [[Atenolol]], [[metoprolol]] (immediate release), [[propranolol]] (immediate release), [[timolol]], [[carvedilol]] (after left ventricular dysfunction), [[bisoprolol]] (preventive treatment before and primary treatment after heart attacks)
* Agents specifically labeled for migraine prophylaxis<ref name="PL Chart Migraine">{{cite web|title=Drugs to Prevent Migraine in Adults|url=https://pharmacist.therapeuticresearch.com/Content/Segments/PRL/2012/Jul/Drugs-to-Prevent-Migraine-in-Adults-4513|website=pharmacist.therapeuticresearch.com|publisher=Therapeutic Research Center|access-date=30 April 2017|url-status=live|archive-url=https://web.archive.org/web/20171018133956/https://pharmacist.therapeuticresearch.com/Content/Segments/PRL/2012/Jul/Drugs-to-Prevent-Migraine-in-Adults-4513|archive-date=October 18, 2017|df=mdy-all}}</ref>
** [[Timolol]], [[propranolol]]

[[Propranolol]] is the only agent indicated for the control of tremor, portal hypertension, and esophageal variceal bleeding, and used in conjunction with α-blocker therapy in [[phaeochromocytoma]].<ref name="Rossi"/>