Editing Antidepressant (section)

===Discontinuation syndrome===
{{Main|Antidepressant discontinuation syndrome}}

Antidepressant discontinuation syndrome, also called antidepressant withdrawal syndrome, is a condition that can occur following the interruption, reduction, or [[Medication discontinuation|discontinuation]] of antidepressant medication.<ref name=War2006/> The symptoms may include [[flu-like symptoms]], trouble sleeping, nausea, poor balance, sensory changes, and [[anxiety]].<ref name=War2006/><ref name=Gab2017/><ref name="Dav2018">{{cite journal|vauthors=Davies J, Read J|title=A systematic review into the incidence, severity and duration of antidepressant withdrawal effects: Are guidelines evidence-based?|journal=Addictive Behaviors|volume=97|pages=111–121|date=October 2019|pmid=30292574|doi=10.1016/j.addbeh.2018.08.027|doi-access=free}}</ref> The problem usually begins within three days and may last for several months.<ref name=War2006/><ref name=Dav2018/> Rarely [[psychosis]] may occur.<ref name=War2006/>

<!-- Risk factors and diagnosis -->
A discontinuation syndrome can occur after stopping any antidepressant including [[selective serotonin reuptake inhibitor]]s (SSRIs), [[serotonin–norepinephrine reuptake inhibitor]]s (SNRIs), and [[tricyclic antidepressants]] (TCAs).<ref name=War2006/><ref name=Gab2017/> The risk is greater among those who have taken the medication for longer and when the medication in question has a short [[half-life]].<ref name=War2006/> The underlying reason for its occurrence is unclear.<ref name=War2006/> The diagnosis is based on the symptoms.<ref name=War2006/>

<!-- Prevention and treatment -->
Methods of prevention include gradually decreasing the dose among those who wish to stop, though it is possible for symptoms to occur with tapering.<ref name=War2006/><ref name=Wil2015/><ref name=Dav2018 /> Treatment may include restarting the medication and slowly decreasing the dose.<ref name=War2006/> People may also be switched to the long-acting antidepressant [[fluoxetine]], which can then be gradually decreased.<ref name=Wil2015/>

<!-- Epidemiology and prognosis -->
Approximately 20–50% of people who suddenly stop an antidepressant develop an antidepressant discontinuation syndrome.<ref name="War2006">{{cite journal|vauthors=Warner CH, Bobo W, Warner C, Reid S, Rachal J|title=Antidepressant discontinuation syndrome|journal=American Family Physician|volume=74|issue=3|pages=449–456|date=August 2006|pmid=16913164}}</ref><ref name=Gab2017/><ref name=Dav2018 /> The condition is generally not serious.<ref name=War2006/> Though about half of people with symptoms describe them as severe.<ref name=Dav2018/> Some restart antidepressants due to the severity of the symptoms.<ref name=Dav2018/>