Editing Zinc (section)

====Weight gain====
{{See also|Zinc deficiency#Appetite}}
Zinc deficiency may lead to loss of appetite.<ref>{{cite journal | vauthors = Suzuki H, Asakawa A, Li JB, Tsai M, Amitani H, Ohinata K, Komai M, Inui A | title = Zinc as an appetite stimulator – the possible role of zinc in the progression of diseases such as cachexia and sarcopenia | journal = Recent Patents on Food, Nutrition & Agriculture | volume = 3 | issue = 3 | pages = 226–231 | date =2011 | pmid = 21846317 | doi = 10.2174/2212798411103030226 }}</ref> The use of zinc in the treatment of anorexia has been advocated since 1979. At least 15 clinical trials have shown that zinc improved weight gain in anorexia. A 1994 trial showed that zinc doubled the rate of body mass increase in the treatment of anorexia nervosa. Deficiency of other nutrients such as tyrosine, tryptophan and thiamine could contribute to this phenomenon of "malnutrition-induced malnutrition".<ref name="Zincappetitereview">{{cite journal|title=Neurobiology of Zinc-Influenced Eating Behavior |journal=The Journal of Nutrition|volume=130|issue=5|pages=1493S–1499S|doi=10.1093/jn/130.5.1493S|pmid=10801965|year=2000|last1=Shay|first1=Neil F.|last2=Mangian|first2=Heather F.|doi-access=free}}</ref>
A meta-analysis of 33 prospective intervention trials regarding zinc supplementation and its effects on the growth of children in many countries showed that zinc supplementation alone had a statistically significant effect on linear growth and body weight gain, indicating that other deficiencies that may have been present were not responsible for growth retardation.<ref name="Zincappetitereview2">{{cite journal|title=Zinc|journal=StatPearls [Internet]|pmid=31613478|year=2019|vauthors=Rabinovich D, Smadi Y}}</ref>